Results 11 to 20 of about 4,066 (198)

Novel exon of mammalian ADAR2 extends open reading frame.

PLoS ONE, 2009
BackgroundThe post-transcriptional processing of pre-mRNAs by RNA editing contributes significantly to the complexity of the mammalian transcriptome. RNA editing by site-selective A-to-I modification also regulates protein function through recoding of ...
Stefan Maas, Willemijn M Gommans
doaj   +3 more sources

When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS [PDF]

Frontiers in Molecular Neuroscience, 2011
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Takuto eHideyama, Takuto eHideyama, Shin eKwak, Shin eKwak   +3 more
doaj   +3 more sources

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]

Nucleic Acids Research, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core   +6 more sources

The effect of ADAR2 in osteosarcoma

Bone Reports, 2020
Michela Rossi, Viviana De Martino, Giulia Battafarano, Eda Mariani, Valeriana Cesarini, Salvatore Minisola, Angela Gallo, Andrea Del Fattore   +7 more
doaj   +2 more sources

Inhibiting ADAR1-Mediated Excessive Epigenetic A-to-I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma. [PDF]

MedComm (2020)
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Wang S, Zheng S, Liu C, Zhang C, Wang X, Wang Z, Wang Y, Feng X, Xue Q, Sun N, He J.   +10 more
europepmc   +2 more sources

The RNA editing enzyme ADAR2 restricts L1 mobility [PDF]

RNA Biology, 2021
Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosines to inosines in double-stranded RNAs (RNA editing A-to-I). ADAR1 and ADAR2 were previously reported as HIV-1 proviral factors. The aim of this study was to investigate the composition of the ADAR2 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity
Frassinelli L., Orecchini E., Al-Wardat S., Tripodi M., Mancone C., Doria M., Galardi S., Ciafre S. A., Michienzi A.   +8 more
openaire   +4 more sources

ADAR2-dependent GluA2 editing regulates cocaine seeking [PDF]

Molecular Psychiatry, 2014
Activation of AMPA receptors (AMPARs) in the nucleus accumbens is necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and relapse. AMPARs are tetrameric protein complexes that consist of GluA1-4 subunits, of which GluA2 imparts calcium permeability. Adenosine deaminase acting on RNA 2 (ADAR2) is a nuclear enzyme
Schmidt, H.D., McFarland, K.N., Darnell, S.B., Huizenga, M.N., Sangrey, G.R., Cha, J.-H.J., Pierce, R.C., Sadri-Vakili, G.   +7 more
openaire   +2 more sources

Substrate recognition by ADAR1 and ADAR2 [PDF]

RNA, 2001
RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver.
S K, Wong, S, Sato, D W, Lazinski
openaire   +2 more sources

Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure. [PDF]

Int J Mol Sci
Mesothelioma is a rare and aggressive cancer linked to asbestos exposure and characterized by rapid metastasis and poor prognosis. Inhibition of adenosine deaminase acting on dsRNA 2 (ADAR2) RNA binding but not ADAR2 editing has shown antitumor effects in mesothelioma.
Ashley CN, Broni E, Pena-Martinez M, Wood CM, Kwofie SK, Miller WA.   +5 more
europepmc   +3 more sources

Altered RNA Editing in Mice Lacking ADAR2 Autoregulation [PDF]

Molecular and Cellular Biology, 2006
ADAR2 is a double-stranded-RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-selective conversion of adenosine to inosine. Previous studies from our laboratory have demonstrated that ADAR2 can modify its own pre-mRNA to create a proximal 3' splice site containing a noncanonical adenosine-inosine dinucleotide ...
Yi, Feng, Christopher L, Sansam, Minati, Singh, Ronald B, Emeson   +3 more
openaire   +2 more sources