Results 21 to 30 of about 4,066 (198)

Gene and RNA Editing: Revolutionary Approaches to Treating Diseases. [PDF]

MedComm (2020)
The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Li JM, Huang J, Liao Y, Hu T, Wang CL, Zhang WZ, Huang CW.   +6 more
europepmc   +2 more sources

A novel RNA pentaloop fold involved in targeting ADAR2 [PDF]

RNA, 2005
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown.
Richard, Stefl, Frédéric H-T, Allain
openaire   +2 more sources

ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations

RNA, 2022
The adenosine deaminase acting on RNA (ADAR) enzymes are essential for neuronal function and innate immune control. ADAR1 RNA editing prevents aberrant activation of antiviral dsRNA sensors through editing of long, double-stranded RNAs (dsRNAs). In this review, we focus on the ADAR2 proteins involved in the efficient, highly site-specific RNA editing ...
Khadija Hajji, Jiří Sedmík, Anna Cherian, Damiano Amoruso, Liam P. Keegan, Mary A. O'Connell   +5 more
openaire   +2 more sources

ADAR1 and ADAR2 Expression and Editing Activity during Forebrain Development [PDF]

Developmental Neuroscience, 2009
The conversion of adenosine to inosine within RNA transcripts is regulated by a family of double-stranded RNA-specific adenosine deaminases referred to as adenosine deaminases that act on RNA (ADARs). Little is known regarding the developmental expression of ADAR family members or the mechanisms responsible for the specific patterns of editing observed
Michelle M, Jacobs, Rachel L, Fogg, Ronald B, Emeson, Gregg D, Stanwood   +3 more
openaire   +2 more sources

Splicing variants of ADAR2 and ADAR2-mediated RNA editing in glioma

Oncology Letters, 2016
The roles of alternative splicing and RNA editing in gene regulation and transcriptome diversity are well documented. Adenosine deaminases acting on RNA (ADARs) are responsible for adenosine-to-inosine (A-to-I) editing and exemplify the complex association between RNA editing and alternative splicing.
Yao, Fu, Xingli, Zhao, Zhaohui, Li, Jun, Wei, Yu, Tian   +4 more
openaire   +3 more sources

ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion [PDF]

Nucleic Acids Research, 2017
Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers. We systematically characterized miRNA expression and editing in the human brain, which displays the highest number of A-to-I RNA editing sites among human tissues, and in de novo glioblastoma brain cancer.
Valeriana Cesarini, Domenico A Silvestris, Valentina Tassinari, Sara Tomaselli, Shahar Alon, Eli Eisenberg, Franco Locatelli, Angela Gallo   +7 more
openaire   +5 more sources

Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma. [PDF]

PLoS ONE, 2014
Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs) associated with characteristic axon degeneration in the optic nerve.
Ai Ling Wang, Reed C Carroll, Scott Nawy
doaj   +1 more source

Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites

ACS Chemical Biology, 2023
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosine in duplex RNA. The inosine product preferentially base pairs with cytidine resulting in an effective A-to-G edit in RNA. ADAR editing can result in a recoding event alongside other alterations to RNA function.
Casey S. Jacobsen, Prince Salvador, John F. Yung, Sabrina Kragness, Herra G. Mendoza, Gail Mandel, Peter A. Beal   +6 more
openaire   +4 more sources

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]

, 2012
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik, Altschul, Andrew C. Penn, Arzumanov, Arzumanov, Balik, Bass, Birney, Brusa, Carver, Daniel, Darty, Dominski, Egebjerg, Eisen, Enstero, Feldmeyer, Gallo, Ge, Greger, Hamada, Heasman, Higuchi, Higuchi, Hogg, Ingo H. Greger, Jepson, Jubin, Katoh, Kent, Kwak, Laurencikiene, Maas, Moulton, Peng, Reenan, Rice, Rosenthal, Rueter, Ryman, Schoft, Sommer, Stephens, Summerton, Summerton, Summerton, Tariq, Traynelis, Valente, Venkatesh, Yamashita, Yang   +51 more
core   +1 more source