Results 31 to 40 of about 1,976 (156)
SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates [PDF]
Nucleic Acids Research, 2018 Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape the editing landscape.
Shanmugam, Raghuvaran +10 more
openaire +3 more sources
Modulation of ADAR mRNA expression in patients with congenital heart defects.
PLoS ONE, 2019 Adenosine (A) to inosine (I) RNA editing is a hydrolytic deamination reaction catalyzed by the adenosine deaminase (ADAR) enzyme acting on double-stranded RNA.
Faiza Altaf +5 more
doaj +1 more source
Cell Reports, 2018 Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis.
Phillip M. Shelton +14 more
doaj +1 more source
RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
core +2 more sources
EMBO Molecular Medicine, 2013 Amyotrophic lateral sclerosis (ALS) is the most common adult‐onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset.
Takenari Yamashita +6 more
doaj +1 more source
Nature Communications, 2020 Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ...
Patricia Deng +11 more
doaj +1 more source
Molecular Oncology, 2022 We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos.
Ananya Hariharan +19 more
doaj +1 more source
New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
core +2 more sources
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
doaj +1 more source
Conservation of A-to-I RNA editing in bowhead whale and pig
PLoS ONE, 2021 RNA editing is a post-transcriptional process in which nucleotide changes are introduced into an RNA sequence, many of which can contribute to proteomic sequence variation.
Knud Larsen, Mads Peter Heide-Jørgensen
doaj +3 more sources