Results 31 to 40 of about 4,066 (198)

Modulation of RNA editing by functional nucleolar sequestration of ADAR2 [PDF]

Proceedings of the National Academy of Sciences, 2003
The adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine (A to I) in primary mRNA transcripts, thereby affecting the splicing pattern or coding potential of mature mRNAs. Although the subnuclear localization of A-to-I editing has not been precisely defined, ADARs have been shown to act before ...
Christopher L, Sansam, K Sam, Wells, Ronald B, Emeson   +2 more
openaire   +2 more sources

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source

Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]

, 2002
RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H., Jaikaran, Dominic C. J., MacMillan, Andrew M.   +2 more
core   +1 more source

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
core   +2 more sources

Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a

Nutrients, 2022
Nonalcoholic fatty liver disease (NAFLD) is a growing health problem that is closely associated with insulin resistance and hereditary susceptibility. Exercise is a beneficial approach to NAFLD. However, the relief mechanism of exercise training is still unknown.
Wang, Zhijing, Zhu, Yaru, Xia, Lu, Li, Jing, Song, Meiyi, Yang, Changqing   +5 more
openaire   +2 more sources

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

eLife, 2022
Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those ...
Dhruva Katrekar, Yichen Xiang, Nathan Palmer, Anushka Saha, Dario Meluzzi, Prashant Mali   +5 more
doaj   +1 more source

RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi. [PDF]

mLife
mLife, Volume 4, Issue 6, Page 597-601, December 2025.
Du Y, Jiang D, Liu H.
europepmc   +2 more sources

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates [PDF]

Nucleic Acids Research, 2018
Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape the editing landscape.
Shanmugam, Raghuvaran, Zhang, Fan, Srinivasan, Harini, Richard, John Lalith Charles, Liu, Kaiwen I., Zhang, Xiujun, Woo, Cheok Wei A., Chua, Zi Hao M., Buschdorf, Jan Paul, Meaney, Michael J., Tan, Meng How   +10 more
openaire   +3 more sources

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9‐ADAR2 delivery to motor neurons

EMBO Molecular Medicine, 2013
Amyotrophic lateral sclerosis (ALS) is the most common adult‐onset motor neuron disease, and the lack of effective therapy results in inevitable death within a few years of onset.
Takenari Yamashita, Hui Lin Chai, Sayaka Teramoto, Shoji Tsuji, Kuniko Shimazaki, Shin‐ichi Muramatsu, Shin Kwak   +6 more
doaj   +1 more source