Results 61 to 70 of about 4,066 (198)

A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar, Eisenberg, Eli, Kaniewska, Paulina, Levanon, Erez, Levy, Oren, Porath, Hagit T., Rosenthal, Joshua J. C., Schaffer, Amos A.   +7 more
core   +1 more source

Affect-related behaviors in mice misexpressing the RNA editing enzyme ADAR2 [PDF]

Physiology & Behavior, 2009
Misediting of the serotonin (5HT) 2C receptor (5HT(2C)R) has been implicated in both depression and anxiety. The adenosine deaminases that act on double stranded RNAs (ADARs) are reported to modify the 5HT(2C)R by RNA editing. Transgenic mice misexpressing the RNA editing enzyme ADAR2 show an adult onset obese phenotype due to chronic hyperphagia, but ...
Minati, Singh, M Bridget, Zimmerman, Terry G, Beltz, Alan Kim, Johnson   +3 more
openaire   +2 more sources

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +1 more source

Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice [PDF]

Journal of Biological Chemistry, 2011
ADAR2, an RNA editing enzyme that converts specific adenosines to inosines in certain pre-mRNAs, often leading to amino acid substitutions in the encoded proteins, is mainly expressed in brain. Of all ADAR2-mediated edits, a single one in the pre-mRNA of the AMPA receptor subunit GluA2 is essential for survival.
Horsch, M., Seeburg, P., Adler, T., Aguilar−Pimentel, J., Becker, L., Calzada−Wack, J., Garrett, L., Götz, A., Hans, W., Higuchi, M., Hölter, S., Naton, B., Prehn, C., Puk, O., Rácz, I., Rathkolb, B., Rozman, J., Schrewe, A., Adamski, J., Busch, D., Esposito, I., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Mempel, M., Ollert, M., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Gailus−Durner, V., Fuchs, H., Hrabe de Angelis, M., Beckers, J.   +34 more
openaire   +5 more sources

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling [PDF]

, 2013
The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Gliomaassociated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a ...
Mohammed Ferdous-Ur, Rahman, Palaniswamy, R., Pivarcsi, A., Shimokawa, T., Sonkoly, E., Ståhle, M., Tostar, U., Zaphiropoulos, P. G.   +7 more
core   +1 more source

Core binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

Blood, 2023
Adenosine to inosine (A-to-I) RNA editing, which is catalyzed by adenosine deaminases acting on RNA (ADAR) family of enzymes ADAR1 and ADAR2, has been shown to contribute to multiple cancers. However, other than chronic myeloid leukemia (CML) blast crisis, relatively little is known about its role in other types of hematological malignancies.
Mingrui Guo, Hon Man Tim Chan, Qi-Ling Zhou, Omer An, Ying Li, Yangyang Song, Zi Hui Tan, Hui En Vanessa Ng, Philomina Sona Peramangalam, Zhi Qing Tan, Xinang Cao, Eisaku Iwanaga, Masao Matsuoka, Melissa G Ooi, Wei Ying Jen, Liang Piu Koh, Esther Chan, Lip Kun Tan, Yufen Goh, Wilson Wang, Bryan T.H. Koh, Ming Chun Chan, Melissa J. Fullwood, Wee Joo Chng, Motomi Osato, John Anto Pulikkan, Henry Yang, Leilei Chen, Daniel G. Tenen   +28 more
openaire   +4 more sources

Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens

Frontiers in Behavioral Neuroscience, 2019
RNA editing plays critical roles in normal brain function, and alteration of its activity causes various disorders. We previously found that chronic consumption of ethanol was associated with increased levels of RNA editing of serotonin 2C receptor in ...
Takahira Shirahase, Takahira Shirahase, Takahira Shirahase, Yoshihisa Watanabe, Atsushi Tsujimura, Shin Kwak, Toshiro Yamamoto, Narisato Kanamura, Masaki Tanaka   +8 more
doaj   +1 more source

ADAR1 restricts LINE-1 retrotransposition [PDF]

, 2016
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra, Ciafré, Silvia Anna, Doria, Margherita, Frassinelli, Loredana, Galardi, Silvia, Mancone, Carmine, Michienzi, Alessandro, Montaldo, Claudia, Orecchini, Elisa, Tripodi, Marco   +9 more
core   +2 more sources

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Structure and Sequence Determinants Required for the RNA Editing of ADAR2 Substrates [PDF]

Journal of Biological Chemistry, 2004
ADAR2 is a double-stranded RNA-specific adenosine deaminase involved in the editing of mammalian RNAs by the site-specific conversion of adenosine to inosine. We have demonstrated previously that ADAR2 can modify its own pre-mRNA, leading to the creation of a proximal 3'-splice junction containing a non-canonical adenosine-inosine (A-I) dinucleotide ...
T Renee, Dawson, Christopher L, Sansam, Ronald B, Emeson   +2 more
openaire   +2 more sources