Results 81 to 90 of about 1,976 (156)

The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]

, 2018
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni, Faggioni, Alberto, J Slack, Frank, Trivedi, Pankaj   +3 more
core   +1 more source

Unveiling the Role of circRNAs in Pyroptotic Signalling: From Molecular Crosstalk to Disease Modulation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Pyroptosis is a gasdermins‐dependent programmed cell death (PCD) characterised by progressive cellular swelling and plasma membrane rupture (PMR). This process releases intracellular contents that amplify inflammatory cascades and immune activation, involving the pathogenesis of various disorders such as tumours, heart and vascular diseases ...
Tengyu Jin, Guodong Xu, Wanru Zhou, Yige Shi, Hebo Wang   +4 more
wiley   +1 more source

Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure

International Journal of Molecular Sciences
Mesothelioma is a rare and aggressive cancer linked to asbestos exposure and characterized by rapid metastasis and poor prognosis. Inhibition of adenosine deaminase acting on dsRNA 2 (ADAR2) RNA binding but not ADAR2 editing has shown antitumor effects in mesothelioma.
Carolyn N. Ashley, Emmanuel Broni, Michelle Pena-Martinez, Chanyah M. Wood, Samuel K. Kwofie, Whelton A. Miller   +5 more
openaire   +2 more sources

Aberrant Expression of ADARB1 Facilitates Temozolomide Chemoresistance and Immune Infiltration in Glioblastoma

Frontiers in Pharmacology, 2022
Chemoresistance, especially temozolomide (TMZ) resistance, is a major clinical challenge in the treatment of glioblastoma (GBM). Exploring the mechanisms of TMZ resistance could help us identify effective therapies.
Can Lu, Xi Chen, Yuanliang Yan, Xinxin Ren, Xiang Wang, Bi Peng, Yuan Cai, Qiuju Liang, Zhijie Xu, Zhijie Xu, Zhijie Xu, Jinwu Peng, Jinwu Peng   +12 more
doaj   +1 more source

Gene and RNA Editing: Revolutionary Approaches to Treating Diseases

MedComm, Volume 6, Issue 10, October 2025.
The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Jia‐Mei Li, Jie Huang, Yan Liao, Ting Hu, Chang‐Li Wang, Wang‐Zheqi Zhang, Chen‐Wei Huang   +6 more
wiley   +1 more source

ADAR2: Towards a Structural and Kinetic Understanding of RNA Editing [PDF]

Biophysical Journal, 2014
Adenosine Deaminases that Act on RNA (ADARs) are a small family of enzymes found in metazoans which edit pre-mRNAs by modifying the base adenosine to inosine. This editing results in translational mutations as inosine is interpreted as guanosine by translational machinery.
Kehr, Andrew D., Macbeth, Mark R., Rule, Gordon S.   +2 more
openaire   +1 more source

Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis

Scientific Reports, 2017
Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still a significant gap in the ...
Tatiana Altadill, Tyrone M. Dowdy, Kirandeep Gill, Armando Reques, Smrithi S. Menon, Cristian P. Moiola, Carlos Lopez-Gil, Eva Coll, Xavier Matias-Guiu, Silvia Cabrera, Angel Garcia, Jaume Reventos, Stephen W. Byers, Antonio Gil-Moreno, Amrita K. Cheema, Eva Colas   +15 more
doaj   +1 more source

Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. [PDF]

PLoS ONE, 2014
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. Mutations in this gene have been identified in patients with X-linked intellectual disability associated with cerebellar ...
Sabina Barresi, Sara Tomaselli, Alekos Athanasiadis, Federica Galeano, Franco Locatelli, Enrico Bertini, Ginevra Zanni, Angela Gallo   +7 more
doaj   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Nomogram Based on A‐To‐I RNA Editing for Predicting Overall Survival in Patients With Breast Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Adenosine‐to‐inosine RNA editing (ATIRE) is the most common type of RNA editing in higher eukaryotes. Many RNA editing events are associated with the occurrence and development of various tumours. Currently, several ATIRE sites have been used as predictors of cancer prognosis.
Yangyang Zhang, Jia Zhou, Hong Li, Dahai Chai, Bin Lian, Yaobang Liu, Li Guo, Jinping Li   +7 more
wiley   +1 more source