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High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images [PDF]

Adipocyte
The aim of this study was to create and validate a high-throughput method based on open-source software for the measurement of adipocyte diameters in white adipose tissue histological sections.
Alan Ramalho, Marie-Frédérique Gauthier, Ina Maltais-Payette, Giada Ostinelli, Frédéric Hould, Laurent Biertho, André Tchernof   +6 more
doaj   +2 more sources

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis

Frontiers in Endocrinology, 2022
STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin in fat cells.
Allison J. Richard, Hardy Hang, Timothy D. Allerton, Peng Zhao, Tamra Mendoza, Sujoy Ghosh, Carrie M. Elks, Jacqueline M. Stephens, Jacqueline M. Stephens   +8 more
doaj   +1 more source

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

Frontiers in Endocrinology, 2022
Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals.
Anik Boudreau, Allison J. Richard, Innocence Harvey, Jacqueline M. Stephens, Jacqueline M. Stephens   +4 more
doaj   +1 more source

TNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1)

Biology, 2023
Impaired adipocyte function contributes to systemic metabolic dysregulation, and altered fat mass or function increases the risk of Type 2 diabetes. EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2), also known as the G9a-like protein
Ashley A. Able, Allison J. Richard, Jacqueline M. Stephens   +2 more
doaj   +1 more source

Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

Scientific Reports, 2021
Brown adipose tissue function declines during aging and may contribute to the onset of metabolic disorders such as diabetes and obesity. Only limited understanding of the mechanisms leading to the metabolic impairment of brown adipocytes during aging ...
Carola Mancini, Sabrina Gohlke, Francisco Garcia-Carrizo, Vyacheslav Zagoriy, Heike Stephanowitz, Tim J. Schulz   +5 more
doaj   +1 more source

The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4

Scientific Reports, 2021
The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization.
Kirsten P. Stone, Sujoy Ghosh, Jean Paul Kovalik, Manda Orgeron, Desiree Wanders, Landon C. Sims, Thomas W. Gettys   +6 more
doaj   +1 more source

Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine

Frontiers in Endocrinology, 2021
FGF21 is a potent metabolic regulator of energy balance, body composition, lipid metabolism, and glucose homeostasis. Initial studies reported that it was increased by fasting and the associated increase in ketones, but more recent work points to the ...
Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys   +4 more
doaj   +1 more source

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Nature Communications, 2022
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim   +14 more
doaj   +1 more source

Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine

iScience, 2021
Summary: Dietary methionine restriction (MR) is normally implemented using diets formulated from elemental amino acids (AA) that reduce methionine content to ∼0.17%. However, translational implementation of MR with elemental AA-based diets is intractable
Han Fang, Kirsten P. Stone, Laura A. Forney, Landon C. Sims, Gabriela C. Gutierrez, Sujoy Ghosh, Thomas W. Gettys   +6 more
doaj   +1 more source

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Nature Communications, 2021
The SWI/SNF complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) play critical roles in enhancer activation, however the interplay between them has remained unclear.
Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O’Haren, Weidong Wang, Weiqun Peng, Kai Ge   +7 more
doaj   +1 more source