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Engineering Human Beige Adipose Tissue
Frontiers in Bioengineering and Biotechnology, 2022 In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age.
Maria A. Gonzalez Porras +7 more
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Frontiers in Endocrinology, 2023 Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity.
Khanyisani Ziqubu +9 more
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Journal of Tissue Engineering, 2022 Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may ...
Francisca M. Acosta +6 more
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Brown and Beige Fat: Therapeutic Potential in Obesity [PDF]
Indonesian Biomedical Journal, 2014 BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
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Protocol for stromal vascular fraction isolation from inguinal subcutaneous white adipose tissue and beige adipocyte differentiation [PDF]
STAR ProtocolsSummary: Research on inducing beige adipocytes to combat obesity and its comorbidities is growing, with stromal vascular fraction (SVF) from white adipose tissue showing potential to differentiate into both white and beige adipocytes.
Qiqi Tang +5 more
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An epigenome atlas of mouse adipocytes [PDF]
Molecular MetabolismObjective: Epigenetic modifications including histone post translational modifications can influence gene expression in adipocytes, potentially contributing to metabolic dysfunctions, obesity, and insulin resistance.
Laura C. Hinte +4 more
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Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo [PDF]
, 2017 This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from ...
Jin, Wanzhu +8 more
core +10 more sources
Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids
Advanced Science, 2023 Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes are emerging as key inducible actors and putative relevant therapeutic targets for improving metabolic health.
Mélanie Escudero +17 more
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Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
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The Role of Thermogenic Fat Tissue in Energy Consumption
Current Issues in Molecular Biology, 2022 Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino +2 more
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