Results 1 to 10 of about 15,625 (221)

Engineering Human Beige Adipose Tissue

Frontiers in Bioengineering and Biotechnology, 2022
In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age.
Maria A. Gonzalez Porras, Maria A. Gonzalez Porras, Katerina Stojkova, Francisca M. Acosta, Christopher R. Rathbone, Christopher R. Rathbone, Eric M. Brey, Eric M. Brey   +7 more
doaj   +3 more sources

Protocol for stromal vascular fraction isolation from inguinal subcutaneous white adipose tissue and beige adipocyte differentiation [PDF]

STAR Protocols
Summary: Research on inducing beige adipocytes to combat obesity and its comorbidities is growing, with stromal vascular fraction (SVF) from white adipose tissue showing potential to differentiate into both white and beige adipocytes.
Qiqi Tang, Juan Xu, Xinyu Yang, Hanni Li, Lingdi Wang, Lu Zhu   +5 more
doaj   +2 more sources

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

Frontiers in Endocrinology, 2023
Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity.
Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Sinenhlanhla X. H. Mthembu, Bongani B. Nkambule, Sihle E. Mabhida, Babalwa U. Jack, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje   +9 more
doaj   +1 more source

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo [PDF]

, 2017
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from ...
Jin, Wanzhu, Król, Elżbieta, Li, Baoguo, Li, Li, Li, Min, Li, Ting, Niu, Chaoqun, Speakman, John R., Wang, Guanlin   +8 more
core   +10 more sources

Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids

Advanced Science, 2023
Obesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes are emerging as key inducible actors and putative relevant therapeutic targets for improving metabolic health.
Mélanie Escudero, Laurence Vaysse, Gozde Eke, Marion Peyrou, Francesc Villarroya, Sophie Bonnel, Yannick Jeanson, Louisa Boyer, Christophe Vieu, Benoit Chaput, Xi Yao, Frédéric Deschaseaux, Mélissa Parny, Isabelle Raymond‐Letron, Christian Dani, Audrey Carrière, Laurent Malaquin, Louis Casteilla   +17 more
doaj   +1 more source

Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions

Journal of Tissue Engineering, 2022
Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may ...
Francisca M. Acosta, Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, Eric M. Brey   +6 more
doaj   +1 more source

Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]

PLoS ONE, 2013
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura, Keigo Fukano, Ayumi Tsubota, Akihiro Uozumi, Akira Terao, Kazuhiro Kimura, Masayuki Saito   +6 more
doaj   +1 more source

The Role of Thermogenic Fat Tissue in Energy Consumption

Current Issues in Molecular Biology, 2022
Mammalian adipose tissues are broadly divided into white adipose tissue (WAT) and thermogenic fat tissue (brown adipose tissue and beige adipose tissue).
Masato Horino, Kenji Ikeda, Tetsuya Yamada   +2 more
doaj   +1 more source

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Frontiers in Endocrinology, 2022
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan, Yong Chen, Yong Chen, Yong Chen   +3 more
doaj   +1 more source

“Beige” Cross Talk Between the Immune System and Metabolism

Frontiers in Endocrinology, 2019
With thymic senescence the epithelial network shrinks to be replaced by adipose tissue. Transcription factor TBX-1 controls thymus organogenesis, however, the same TBX-1 has also been reported to orchestrate beige adipose tissue development.
Krisztina Banfai, Krisztina Banfai, David Ernszt, David Ernszt, Attila Pap, Peter Bai, Peter Bai, Peter Bai, Peter Bai, Kitti Garai, Kitti Garai, Djeda Belharazem, Judit E. Pongracz, Judit E. Pongracz, Krisztian Kvell, Krisztian Kvell   +15 more
doaj   +1 more source