Results 181 to 190 of about 15,625 (221)
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Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?
Physiology, 2021Obesity research progresses in understanding neuronal circuits and adipocyte biology to regulate metabolism. However, the interface of neuro-adipocyte interaction is less studied. We summarize the current knowledge of adipose tissue innervation and interaction with adipocytes and emphasize adipocyte transitions from white to brown adipocytes and vice ...
Heike Münzberg +2 more
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The Gq signalling pathway inhibits brown and beige adipose tissue [PDF]
Nature Communications, 2016 AbstractBrown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of
Thorsten Gnad +2 more
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Inducible brown/beige adipocytes in retro-orbital adipose tissues
Experimental Eye Research, 2019Beige adipocytes and brown adipocytes can generate heat by using mitochondrial uncoupling protein 1 (Ucp1), a thermogenic protein. Browning/beiging is the emergence of beige adipocytes in white adipose tissues (WAT) for cold acclimatization. Here we show the existence of brown/beige adipocytes in retro-orbital WAT in mice. Histologically, Ucp1-positive
Makoto, Sugiyama +6 more
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Aging of Brown and Beige/Brite Adipose Tissue
2018Brown adipose tissue aging and the concomitant loss of thermogenic capacity have been linked to an inability to maintain normal energy homeostasis in late life. Similarly, the ability of white fat to convert into brite/beige adipose tissue declines. This may ultimately exacerbate the progression of age-related metabolic pathologies, such as insulin ...
Antonia, Graja +2 more
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Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue
The FASEB Journal, 2020Abstract Regulatory T cells (Tregs) play essential roles in obesity and diabetes. Here, we report a role of Tregs in enhancing β3‐adrenergic receptor agonist CL316243 (CL)‐stimulated thermogenic program in subcutaneous adipose tissue (SAT), but not in visceral fat.
Wenqian, Fang +5 more
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Transcriptome profile of white, brown and beige adipose tissue
The FASEB Journal, 2022Adipose tissue dysregulation lies at the core metabolic syndrome. White adipose tissue (WAT) has the capacity to store energy, whereas brown adipose tissue (BAT) can dissipate energy through thermogenesis. Newly discovered beige adipocytes are brown like adipocytes recruited in WAT in response to b3‐adrenergic stimulation (CL316 ...
Henry Paz +4 more
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Brown and Beige Adipose Tissues in Health and Disease
Comprehensive Physiology, 2017ABSTRACTBrown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue (BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat develops postnatally and is highly inducible. Beige fat recruitment is mediated by multiple mechanisms, including de novo beige adipogenesis and white‐to‐brown ...
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ADIPOGENESIS FEATURES OF WHITE, BEIGE AND BROWN ADIPOSE TISSUES
BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2021White and brown adipose tissue is present in the human body and is well described. As well as the effect of the type of fat on human health, in particular obesity, type 2 diabetes, insulin tolerance. The presence and distribution of different types of fat in pigs has not been adequately described.
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Dynamic contrast‐enhanced MRI of brown and beige adipose tissues
Magnetic Resonance in Medicine, 2019PurposeThe vascular blood flow in brown adipose tissue (BAT) is important for handling triglyceride clearance, increased blood flow and oxygenation. We used dynamic contrast‐enhanced (DCE)‐MRI and fat fraction (FF) imaging for investigating vascular perfusion kinetics in brown and beige adipose tissues with cold exposure or treatment with β3‐adrenergic
Jadegoud Yaligar +8 more
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