Results 11 to 20 of about 15,625 (221)
Bioengineering beige adipose tissue therapeutics [PDF]
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +3 more sources
Brown and Beige Adipose Tissue and Aging [PDF]
Frontiers in Endocrinology, 2019 Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes dysfunctional with an increase in production of inflammatory peptides, a decline of those with anti-inflammatory activity and infiltration of macrophages.
Elena Zoico +7 more
doaj +4 more sources
Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging
CellsAdipose tissue beiging refers to the process by which beige adipocytes emerge in classical white adipose tissue depots. Beige adipocytes dissipate chemical energy and secrete adipokines, such as classical brown adipocytes, to improve systemic metabolism,
Xi Chen +8 more
doaj +4 more sources
Maintaining mitochondria in beige adipose tissue [PDF]
Adipocyte, 2019 Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve ...
Xiaodan Lu
doaj +3 more sources
Beige Adipose Tissue Identification and Marker Specificity—Overview [PDF]
Frontiers in Endocrinology, 2021 Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that uniquely differentiate beige AT (BeAT) remain to be fully elaborated.
Anna-Claire Pilkington +4 more
openaire +3 more sources
Mirabegron: The most promising adipose tissue beiging agent [PDF]
Physiological Reports, 2021 Accumulation of white adipose tissue (WAT) underlies the obesity epidemic, leading to current therapeutic techniques that are being investigated for their ability to activate/"beige" this tissue. Adipose tissue (AT) beiging has been reported through intermittent cold exposure (CE), exercise, and β3-Adrenergic Receptor (β3AR) agonists.
Jocelyn S. Bel +3 more
openaire +3 more sources
MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso +13 more
openaire +2 more sources
Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re-esterification via Glycerol Kinase Upregulation. [PDF]
Adv Sci (Weinh)Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Sun J +16 more
europepmc +2 more sources
Hydrogel-based engineering of beige adipose tissue [PDF]
Journal of Materials Chemistry B, 2015 Brown and beige adipose tissues have a significant capacity for energy expenditure that may be exploited as a treatment for obesity and metabolic disease.
M K, Vaicik +8 more
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Matrix-Assisted Transplantation of Functional Beige Adipose Tissue [PDF]
Diabetes, 2015 Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.
Tharp, Kevin M +8 more
openaire +4 more sources