Results 1 to 10 of about 4,687 (169)
Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes [PDF]
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
doaj +4 more sources
Molecular characterization of a novel intracellular ADP-ribosyl cyclase. [PDF]
PLoS ONE, 2007 BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani +9 more
doaj +5 more sources
L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization. [PDF]
PLoS ONE, 2017 Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly +3 more
doaj +2 more sources
Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases [PDF]
Advanced ScienceArmed with two distinct targeting moieties, artificially created bispecific agents can uniquely modulate various processes and events implicated in human health and diseases.
Sunny H. Kim +8 more
doaj +2 more sources
A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases [PDF]
Nature CommunicationsCell-secreted exosomes have been emerging as an increasingly attractive form of nanomaterials for biomedical research. Various approaches have been established to genetically modify exosomes with proteins of interest for new and/or improved functions ...
Lei Zhang +11 more
doaj +2 more sources
ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]
Messenger, 2016 ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP.
Dale, L +4 more
core +8 more sources
Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform. [PDF]
Biochem J, 2004 The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Bacher I +3 more
europepmc +5 more sources
CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain. [PDF]
Biochem J, 2003 CD38 is a transmembrane glycoprotein that is expressed in many tissues throughout the body. In addition to its major NAD+-glycohydrolase activity, CD38 is also able to synthesize cyclic ADP-ribose, an endogenous calcium-regulating molecule, from NAD+.
Ceni C +10 more
europepmc +4 more sources
Structure, 2004 ADP-ribosyl cyclase catalyzes the elimination of nicotinamide from NAD and cyclization to cADPR, a known second messenger in cellular calcium signaling pathways. We have determined to 2.0 Å resolution the structure of Aplysia cyclase with ribose-5-phosphate bound covalently at C3′ and with the base exchange substrate (BES), pyridylcarbinol, bound to ...
Love, Michael L +7 more
openaire +5 more sources
Сибирский научный медицинский журнал, 2021 The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova +4 more
doaj +1 more source