Results 11 to 20 of about 4,754 (181)
ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin [PDF]
Messenger, 2016 ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP.
Dale, L +4 more
core +8 more sources
The Na<sup>+</sup>/K<sup>+</sup>-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]
FASEB JThis study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc +2 more sources
Structure, 2004 ADP-ribosyl cyclase catalyzes the elimination of nicotinamide from NAD and cyclization to cADPR, a known second messenger in cellular calcium signaling pathways. We have determined to 2.0 Å resolution the structure of Aplysia cyclase with ribose-5-phosphate bound covalently at C3′ and with the base exchange substrate (BES), pyridylcarbinol, bound to ...
Love, Michael L +7 more
openaire +5 more sources
CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1. [PDF]
IUBMB LifeAbstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Dogan S +5 more
europepmc +2 more sources
Cd38/Adp-Ribosyl Cyclase [PDF]
The Journal of Cell Biology, 1999 The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD+ to cyclic ADP-ribose (cADPr). The latter gates Ca2+ release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library.
Li Sun +16 more
openaire +1 more source
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
doaj +1 more source
Characterization of the Active Site of ADP-ribosyl Cyclase [PDF]
Journal of Biological Chemistry, 1999 ADP-ribosyl cyclase synthesizes two Ca(2+) messengers by cyclizing NAD to produce cyclic ADP-ribose and exchanging nicotinic acid with the nicotinamide group of NADP to produce nicotinic acid adenine dinucleotide phosphate. Recombinant Aplysia cyclase was expressed in yeast and co-crystallized with a substrate, nicotinamide.
Walseth, TF +5 more
openaire +4 more sources
Ectonucleotidases in Acute and Chronic Inflammation
Frontiers in Pharmacology, 2021 Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani +2 more
doaj +1 more source
iScience, 2022 Summary: SARM1 is an NAD(P) glycohydrolase and TLR adapter with an essential, prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD(P)ases, it catalyzes multiple reactions that need to be fully investigated.
Carlo Angeletti +8 more
doaj +1 more source
Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
Biomolecules, 2021 It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli +3 more
doaj +1 more source