Results 31 to 40 of about 4,754 (181)
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome [PDF]
, 2014 Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic ...
Barbosa, Maria Thereza +9 more
core +1 more source
Scientific Reports, 2021 Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi +10 more
doaj +1 more source
ADP-Ribosyl Cyclase in Rat Vascular Smooth Muscle Cells [PDF]
Circulation Research, 2000 Abstract —We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs) has enzymatic properties that differ from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells. ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by gangliosides
F G, de Toledo +4 more
openaire +2 more sources
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Frontiers in Genetics, 2022 Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu +10 more
doaj +1 more source
Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS [PDF]
, 2015 ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP ...
Colanzi, Antonino +2 more
core +1 more source
The roles of oxytocin and CD38 in social or parental behaviors
Frontiers in Neuroscience, 2013 The nine amino acid peptide oxytocin (OXT) has been directly associated with different types of behavioral reactions. The formation and maintenance of social relationships in youth and middle age are important components of human mental health. A deficit
Olga eLopatina +3 more
doaj +1 more source
Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal-mediated headshaking. [PDF]
, 2019 BackgroundOral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses.ObjectiveEvaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses ...
Aleman, Monica +5 more
core +2 more sources
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich +16 more
wiley +2 more sources
ADP‐ribosyl cyclase coupled with receptors via G proteins [PDF]
FEBS Letters, 1997 Crude cell membranes in mammalian cells contain ADP‐ribosyl cyclase, which converts NAD+ to cyclic ADP‐ribose. Acetylcholine either increases or inhibits this activity in NG108‐15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor subtype‐specific manner.
openaire +2 more sources
Scientific Reports, 2021 CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv +9 more
doaj +1 more source