Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs [PDF]
, 2018 Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts.
Borbone, Nicola +10 more
core +2 more sources
Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases [PDF]
Science Advances, 2020 A new approach is developed for generating site-specific antibody-drug conjugates for targeted therapy.
Zhefu Dai +11 more
openaire +2 more sources
Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS [PDF]
, 2015 ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP ...
Colanzi, Antonino +2 more
core +1 more source
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome [PDF]
, 2014 Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic ...
Barbosa, Maria Thereza +9 more
core +1 more source
ADP-Ribosyl Cyclase in Rat Vascular Smooth Muscle Cells [PDF]
Circulation Research, 2000 Abstract —We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs) has enzymatic properties that differ from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells. ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by gangliosides
F G, de Toledo +4 more
openaire +2 more sources
Scientific Reports, 2021 Herein proteomic profiling of the rat hippocampus from the kindling and pilocarpine models of epilepsy was performed to achieve new potential targets for treating epileptic seizures.
Leila Sadeghi +10 more
doaj +1 more source
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Frontiers in Genetics, 2022 Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu +10 more
doaj +1 more source
The roles of oxytocin and CD38 in social or parental behaviors
Frontiers in Neuroscience, 2013 The nine amino acid peptide oxytocin (OXT) has been directly associated with different types of behavioral reactions. The formation and maintenance of social relationships in youth and middle age are important components of human mental health. A deficit
Olga eLopatina +3 more
doaj +1 more source
Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal-mediated headshaking. [PDF]
, 2019 BackgroundOral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses.ObjectiveEvaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses ...
Aleman, Monica +5 more
core +2 more sources
Immuno-targeting the multifunctional CD38 using nanobody [PDF]
, 2016 published_or_final_versio
Deng, QW +14 more
core +1 more source