Results 51 to 60 of about 4,754 (181)

Impaired learning and memory in CD38 null mutant mice [PDF]

, 2016
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores.
Jang, Eun-Hye, Kaang, Bong-Kiun, Kang, Minkyung, Kim, Jae-Ick, Kim, Sang Jeong, Kim, Somi, Kim, TaeHyun, Kim, Uh-Hyun, Lee, Bolam, Lee, Hye-Ryeon, Lee, Yong-Seok, Lim, Chae Seok, Rah, So-Young, Ryu, Hyun-Hee, Yoo, Juyoun   +14 more
core   +1 more source

Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy [PDF]

Cardiovascular Research, 2008
Here, we report the discovery of a small molecule inhibitor, 2,2'-dihydroxyazobenzene (DAB), of ADP ribosyl cyclase (ADPR-cyclase) and showed that this inhibitor attenuated angiotensin (Ang) II-induced hypertrophic responses.and results The intracellular concentration of free Ca(2+) [Ca(2+)](i) in adult rat cardiomyocytes was measured by using a ...
Rukhsana, Gul, Jae-Hyeong, Park, Seon-Young, Kim, Kyu Yoon, Jang, Jei-Keon, Chae, Jae-Ki, Ko, Uh-Hyun, Kim   +6 more
openaire   +2 more sources

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease

Frontiers in Behavioral Neuroscience, 2014
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in
Olga eLopatina, Toru eYoshihara, Tomoko eNishimura, Jing eZhong, Shirin eAkther, Azam AKM Fakhrul, Mingkun eLiang, Chiharu eHigashida, Kohei eSumi, Kazumi eFuruhara, Yuki eInahata, Jianjun eHuang, Keita eKoizumi, Shigeru eYokoyama, Takahiro eTsuji, Yu ePetugina, Andrei eSumarukov, Alla B. Salmina, Koji eHashida, Yasuko eKitao, Osamu eHori, Masahide eAsano, Yoji eKitamura, Takashi eKozaka, Kazuhiro eShiba, Fangfang eZhong, Min-Jue eXie, Makoto eSato, Katsuhiko eIshihara, Haruhiro eHigashida   +29 more
doaj   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

Purification and characterization of CD38/ADP‐ribosyl cyclase from rat lung [PDF]

IUBMB Life, 1998
AbstractPurification and characterization of CD38/ADP‐ribosyl cyctase in the rat lung tissue was performed with microsomes solubilized in Triton X‐100 and the ADP‐ribosyl cyclase was then purified using sequential column chromatography. Partially purified rat lung ADP‐ribosyl cyclase was analyzed by immunoblotting using an antibody raised against a ...
Khoo, K.M., Chang, C.F.
openaire   +2 more sources

Design, synthesis and biological characterization of novel inhibitors of CD38 [PDF]

, 2011
Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca 2+ messenger molecule, cyclic ADP-ribose, from NAD +.
Cheung Lee, H, Dong, M, Hao, Q, Kriksunov, IA, Kwong, AKY, Lam, CMC, Leung, FP, Pu, XP, Si, YQ, Sun, SY, Yang, ZJ, Yue, J, Zhang, LH, Zhang, LR, Zhou, Y   +14 more
core   +1 more source

Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform. [PDF]

Biochem J, 2004
The novel Ca2+-mobilizing second messengers cADPr (cyclic ADP-ribose) and NAADP (nicotinic acid–adenine dinucleotide phosphate) are both synthesized by ADP-ribosyl cyclases. Using HSR (heavy sarcoplasmic reticulum) fractions from rabbit skeletal muscle, NAADP-induced Ca2+ release was observed.
Bacher I, Zidar A, Kratzel M, Hohenegger M.   +3 more
europepmc   +5 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs [PDF]

Frontiers in Bioscience, 2014
The major ADP-ribosylating enzyme families are the focus of this special issue of Frontiers in Bioscience . However, there is room for another family of enzymes with the capacity to utilize nicotinamide adenine dinucleotide (NAD): the ADP-ribosyl cyclases (ARCs).
FERRERO, Enza, LO BUONO, NICOLA, HORENSTEIN, ALBERTO, FUNARO, Ada, MALAVASI, Fabio   +4 more
openaire   +3 more sources