Results 61 to 70 of about 4,754 (181)

Sex, Receptors and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

Frontiers in Neuroscience, 2013
As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (IN OT) is demonstrating a growing potential as a therapeutic agent in psychiatry.
Kai S Macdonald
doaj   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Cyclic ADP ribose is a novel regulator of intracellular Ca 2+ oscillations in human bone marrow mesenchymal stem cells [PDF]

, 2011
Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, the cellular biology of these cells is not fully understood. The present study characterizes the cyclic ADP-ribose (cADPR)-mediated Ca 2+ signals in
Lau, CP, Lee, HC, Li, GR, Sun, HY, Tao, R, Tse, HF   +5 more
core   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Модуляция активности АДФ-рибозилциклазы при ишемии головного мозга [PDF]

, 2012
Второе место среди причин смертности и инвалидизации больных занимают острые нарушения мозгового кровообращения. Цель исследования - оценить влияние модуляторов активности АДФ-рибозилциклазы/CD38 в нейронах и клетках нейроглиальной природы в ...
Баглаева, Ольга Владимировна, Гасымлы, Эльтадж Джамил кызы, Кувачева, Наталья Валерьевна, Малиновская, Наталия Александровна, Морозова, Галина Александровна, Панина, Юлия Анатольевна, Петрова, Марина Михайловна, Салмина, Алла Борисовна, Фролова, Ольга Васильевна   +8 more
core  

Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal. [PDF]

, 2011
BACKGROUND: The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow waves.
Caldas, Carlos, Daigo, Yataro, Fujino, Masayuki A, Ponder, Bruce AJ, Sanders, Kenton M, Takayama, Ichiro, Ward, Sean M   +6 more
core   +1 more source

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source

Membrane-translocating peptides and toxins: from nature to bedside [PDF]

, 2008
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie, Kerkis, Alexandre, Kerkis, Irina, Prieto-Silva, Álvaro Rossan, Rádis-Baptista, Gandhi, Tetsuo, Yamane   +5 more
core   +1 more source

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-na\uefve chronic lymphocytic leukemia [PDF]

, 2016
ADP-ribosyl Cyclase 1; Disease Progression; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable[no abstract ...
Ambrosetti, Achille, Cavallini, Chiara, Cesano, Alessandra, Facco, Monica, Falisi, Erika, Gaidano, Gianluca, Lovato, Ornella, Mimiola, Elda, Perbellini, Omar, Pizzolo, Giovanni, Purvis, Norman, Putta, Santosh, Romanelli, Maria Giovanna, Rossi, Davide, Scupoli, Maria T., Semenzato, Gianpietro Carlo, Trentin, Livio, Visco, Carlo   +17 more
core   +3 more sources