Results 61 to 70 of about 4,726 (204)

Cyclic ADP ribose is a novel regulator of intracellular Ca 2+ oscillations in human bone marrow mesenchymal stem cells [PDF]

, 2011
Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, the cellular biology of these cells is not fully understood. The present study characterizes the cyclic ADP-ribose (cADPR)-mediated Ca 2+ signals in
Lau, CP, Lee, HC, Li, GR, Sun, HY, Tao, R, Tse, HF   +5 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal. [PDF]

, 2011
BACKGROUND: The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow waves.
Caldas, Carlos, Daigo, Yataro, Fujino, Masayuki A, Ponder, Bruce AJ, Sanders, Kenton M, Takayama, Ichiro, Ward, Sean M   +6 more
core   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source

Membrane-translocating peptides and toxins: from nature to bedside [PDF]

, 2008
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie, Kerkis, Alexandre, Kerkis, Irina, Prieto-Silva, Álvaro Rossan, Rádis-Baptista, Gandhi, Tetsuo, Yamane   +5 more
core   +1 more source

Модуляция активности АДФ-рибозилциклазы при ишемии головного мозга [PDF]

, 2012
Второе место среди причин смертности и инвалидизации больных занимают острые нарушения мозгового кровообращения. Цель исследования - оценить влияние модуляторов активности АДФ-рибозилциклазы/CD38 в нейронах и клетках нейроглиальной природы в ...
Баглаева, Ольга Владимировна, Гасымлы, Эльтадж Джамил кызы, Кувачева, Наталья Валерьевна, Малиновская, Наталия Александровна, Морозова, Галина Александровна, Панина, Юлия Анатольевна, Петрова, Марина Михайловна, Салмина, Алла Борисовна, Фролова, Ольга Васильевна   +8 more
core  

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR).
Aarhus, Balázs Tóth, Beck, Brailoiu, Calcraft, Churamani, Csanády, Fliegert, Fonfria, Hara, Hermosura, Iordan Iordanov, Kaneko, Koch-Nolte, Kolisek, Lange, Lin, László Csanády, Malavasi, McHugh, Moreau, Nagamine, Olah, Perraud, Perraud, Perraud, Perraud, Sano, Schmid, Togashi, Tóth, Tóth, Tóth, Uchida, Wang, Wehage, Yamamoto   +36 more
core   +2 more sources

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-na\uefve chronic lymphocytic leukemia [PDF]

, 2016
ADP-ribosyl Cyclase 1; Disease Progression; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable[no abstract ...
Ambrosetti, Achille, Cavallini, Chiara, Cesano, Alessandra, Facco, Monica, Falisi, Erika, Gaidano, Gianluca, Lovato, Ornella, Mimiola, Elda, Perbellini, Omar, Pizzolo, Giovanni, Purvis, Norman, Putta, Santosh, Romanelli, Maria Giovanna, Rossi, Davide, Scupoli, Maria T., Semenzato, Gianpietro Carlo, Trentin, Livio, Visco, Carlo   +17 more
core   +3 more sources