Results 1 to 10 of about 7,475 (210)

Aerobactin-Mediated Iron Acquisition Enhances Biofilm Formation, Oxidative Stress Resistance, and Virulence of Yersinia pseudotuberculosis

Frontiers in Microbiology, 2021
Aerobactin is a citrate-hydroxamate siderophore that is critical for the virulence of pathogenic enteric bacteria. However, although the aerobactin-producing iucABCD-iutA operon is distributed widely in the genomes of Yersinia species, none of the ...
Yao Wang, Zhi-Qiang Lu, Lingfang Zhu
exaly   +3 more sources

Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae ST37: genomic and phenotypic characterization of virulence and resistance [PDF]

Frontiers in Microbiology
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) ST37 necessitates urgent reassessment of its pathogenic potential. This study aims to characterize the genomic and phenotypic features of ST37 isolates collected from a ...
Li Shen, Weihua Han, Yu Huang, Shanshan Wang, Haojin Gao, Jinjin Yang, Jiana Fu, Zhixuan Chen, Junhong Shi, Xinru Yuan, Jingyi Yu, Fangyou Yu, Chunyang Wu   +12 more
doaj   +2 more sources

The iucC gene is a major contributor to the virulence of hypervirulent Klebsiella pneumoniae [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundHypervirulent Klebsiella pneumoniae (hvKp) is a critical pathogen that causes highly lethal invasive infections with its virulence linked to that of aerobactin, the core siderophore system of hvKp.MethodsHere, 20 porcine-derived K.
Chong Chen, Li Wang, Shuo Zu, Hui Ning, Liran Song, Jianbao Dong, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Yalu Ji, Jingmin Gu, Jingmin Gu   +12 more
doaj   +2 more sources

Effects of aerobactin-encoding gene iucB and regulator of mucoid phenotype rmpA on the virulence of Klebsiella pneumoniae causing liver abscess

Frontiers in Cellular and Infection Microbiology, 2022
This study aimed to analyze the influence of the main aerobactin-encoding gene iucB and the regulator of mucoid phenotype rmpA on the virulence of Klebsiella pneumoniae causing liver abscess.
Tieli Zhou
exaly   +3 more sources

Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024 [PDF]

Eurosurveillance
An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 Klebsiella pneumoniae isolates from eight European ...
Anke Kohlenberg
doaj   +2 more sources

Genome-Based Analysis of Klebsiella spp. Isolates from Animals and Food Products in Germany, 2013–2017

Pathogens, 2021
The increase in infections with multidrug-resistant and virulent Klebsiella pneumoniae (K. pneumoniae) strains poses a serious threat to public health. However, environmental reservoirs and routes of transmission for Klebsiella spp. that cause infections
Kathleen Klaper, Jens Andre Hammerl, Jörg Rau, Yvonne Pfeifer, Guido Werner   +4 more
doaj   +1 more source

Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2)

Antibiotics, 2022
Hypervirulent K. pneumoniae (hvKP) strains possess distinct characteristics such as hypermucoviscosity, unique serotypes, and virulence factors associated with high pathogenicity.
Hisham N. Altayb, Hana S. Elbadawi, Othman Baothman, Imran Kazmi, Faisal A. Alzahrani, Muhammad Shahid Nadeem, Salman Hosawi, Kamel Chaieb   +7 more
doaj   +1 more source

Iron-Utilization System in Vibrio vulnificus M2799

Marine Drugs, 2021
Vibrio vulnificus is a Gram-negative pathogenic bacterium that causes serious infections in humans and requires iron for growth. A clinical isolate, V. vulnificus M2799, secretes a catecholate siderophore, vulnibactin, that captures ferric ions from the ...
Katsushiro Miyamoto, Hiroaki Kawano, Naoko Okai, Takeshi Hiromoto, Nao Miyano, Koji Tomoo, Takahiro Tsuchiya, Jun Komano, Tomotaka Tanabe, Tatsuya Funahashi, Hiroshi Tsujibo   +10 more
doaj   +1 more source

Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundThe incidence of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella pneumoniae (Kp) is increasing globally among various clones and is also responsible for nosocomial infections.
Chaitra Shankar, Soumya Basu, Binesh Lal, Sathiya Shanmugam, Karthick Vasudevan, Purva Mathur, Sudha Ramaiah, Anand Anbarasu, Balaji Veeraraghavan   +8 more
doaj   +1 more source

Characteristics of Hypervirulent Klebsiella pneumoniae: Does Low Expression of rmpA Contribute to the Absence of Hypervirulence?

Frontiers in Microbiology, 2020
Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) has been increasingly reported and is now recognized as a significant threat to public health; however, characterization of MDR-hvKP has not been systematically investigated.
Zhi-wei Lin, Zhi-wei Lin, Jin-xin Zheng, Jin-xin Zheng, Bing Bai, Guang-jian Xu, Fo-jun Lin, Zhong Chen, Zhong Chen, Xiang Sun, Di Qu, Zhi-jian Yu, Qi-wen Deng   +12 more
doaj   +1 more source