Results 1 to 10 of about 5,959 (186)

Aerobactin is a key driver of hypervirulent Klebsiella pneumoniae translocation and virulence. [PDF]

PLoS Pathogens
Hypervirulent Klebsiella pneumoniae (hvKP) is an emerging pathotype capable of causing severe systemic infections. Gastrointestinal (GI) colonization often precedes invasive disease, but the mechanisms driving translocation to extra-intestinal sites are ...
Giovanna E Hernandez, Juan D Valencia-Bacca, Emma F Bennett, Md Maidul Islam, Suhrid Maiti, Noah A Nutter, Taylor M Young, David L Caudell, Alicia Costa-Terryll, Jaden J Skelly, Edison T Floyd, Hannah M Atkins, M Ammar Zafar   +12 more
doaj   +4 more sources

The pathogenicity of or aerobactin-positive in infected mice [PDF]

Journal of International Medical Research, 2019
Objectives To investigate the pathogenicity of Klebsiella pneumoniae (KPN) possessing rmpA or the aerobactin gene in infected mice. Methods BALB/c mice were divided into four groups (n = 10 per group) and infected with: string test-positive and rmpA ...
Guili Li, Shuhong Sun, Zhong Yuan Zhao, Yunfang Sun   +3 more
doaj   +4 more sources

Aerobactin-Mediated Iron Acquisition Enhances Biofilm Formation, Oxidative Stress Resistance, and Virulence of Yersinia pseudotuberculosis

Frontiers in Microbiology, 2021
Aerobactin is a citrate-hydroxamate siderophore that is critical for the virulence of pathogenic enteric bacteria. However, although the aerobactin-producing iucABCD-iutA operon is distributed widely in the genomes of Yersinia species, none of the ...
Xihui Shen, Zhi-Qiang Lu, Yao Wang
exaly   +3 more sources

Growth Stimulation of Escherichia coli in Serum by Iron(III) Aerobactin. Recycling of Aerobactin [PDF]

FEMS Microbiology Letters, 1984
Growth of wild-type strains and K-12 derivatives of Escherichia coli in calf serum was strongly enhanced by the iron(III) aerobactin supply system specified by certain ColV plasmids. Aerobactin was superior over enterochelin in stimulating growth. In contrast to enterochelin and ferrichrome, aerobactin seemed not to be hydrolyzed or modified during ...
Volkmar Braun, V Braun
exaly   +3 more sources

Effects of Aerobactin-Encoding Gene iucB and Regulator of Mucoid Phenotype rmpA on the Virulence of Klebsiella pneumoniae Causing Liver Abscess

Frontiers in Cellular and Infection Microbiology, 2022
This study aimed to analyze the influence of the main aerobactin-encoding gene iucB and the regulator of mucoid phenotype rmpA on the virulence of Klebsiella pneumoniae causing liver abscess.
Mengxin Xu, Cui Zhou, Yining Zhao
exaly   +3 more sources

Virulome–resistome convergence in swine-associated multidrug-resistant Escherichia coli from Hungary: virulence marker profiles and zoonotic potential [PDF]

Frontiers in Veterinary Science
BackgroundSwine production can sustain dense reservoirs of multidrug-resistant (MDR) Escherichia coli in which mobilizable resistance may co-occur with virulence modules relevant to animal health and One Health risk. We profiled the virulome of Hungarian
Ádám Kerek, Ádám Kerek, Balázs Nagyházi, Gergely Álmos Tornyos, Gergely Álmos Tornyos, Levente Hunor Husz, Levente Hunor Husz, Máté Hetyésy, Máté Hetyésy, Eszter Kaszab, Eszter Kaszab, Eszter Kaszab, Eszter Kaszab, Enikő Fehér, Enikő Fehér, Enikő Fehér, Enikő Fehér, Patrik Mag, Patrik Mag, Ákos Jerzsele, Ákos Jerzsele   +20 more
doaj   +2 more sources

Structural and Functional Delineation of Aerobactin Biosynthesis in Hypervirulent Klebsiella pneumoniae [PDF]

Journal of Biological Chemistry, 2018
Aerobactin, a citryl-hydroxamate siderophore, is produced by a number of pathogenic Gram-negative bacteria to aid in iron assimilation. Interest in this well-known siderophore was reignited by recent investigations suggesting that it plays a key role in mediating the enhanced virulence of a hypervirulent pathotype of Klebsiella pneumoniae (hvKP).
Courtney C Aldrich, Lisa S Mydy, Matthew Rice   +2 more
exaly   +3 more sources

Aerobactin: A Multifaceted Siderophore

Indian Journal of Microbiology
Different bacteria produce different iron(III) chelating small molecules called siderophores to fetch iron(III) from the surrounding environment. Aerobactin is a hydroxamate siderophore discovered in Aerobacter aerogenes in 1969. Aerobactin synthesizing and importing proteins are encoded by iuc-iutA operon which was found to confer growth advantage in ...
Subho Ghosh
exaly   +3 more sources

Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae ST37: genomic and phenotypic characterization of virulence and resistance [PDF]

Frontiers in Microbiology
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) ST37 necessitates urgent reassessment of its pathogenic potential. This study aims to characterize the genomic and phenotypic features of ST37 isolates collected from a ...
Li Shen, Weihua Han, Yu Huang, Shanshan Wang, Haojin Gao, Jinjin Yang, Jiana Fu, Zhixuan Chen, Junhong Shi, Xinru Yuan, Jingyi Yu, Fangyou Yu, Chunyang Wu   +12 more
doaj   +2 more sources

Genome-Based Analysis of Klebsiella spp. Isolates from Animals and Food Products in Germany, 2013–2017

Pathogens, 2021
The increase in infections with multidrug-resistant and virulent Klebsiella pneumoniae (K. pneumoniae) strains poses a serious threat to public health. However, environmental reservoirs and routes of transmission for Klebsiella spp. that cause infections
Kathleen Klaper, Jens Andre Hammerl, Jörg Rau, Yvonne Pfeifer, Guido Werner   +4 more
doaj   +1 more source