Results 11 to 20 of about 9,776,047 (207)

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +2 more sources

Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults

BMC Medical Genomics
Background Dyslipidemia, which is characterized by an unfavorable lipid profile, is a key risk factor for cardiovascular disease (CVD). Understanding the relationships between epigenetic aging and lipid levels may help guide early prevention and ...
Lisha Lin, Jenna Kiryakos, Farah Ammous, Scott M. Ratliff, Erin B. Ware, Jessica D. Faul, Sharon L.R. Kardia, Wei Zhao, Kira S. Birditt, Jennifer A. Smith   +9 more
doaj   +2 more sources

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis. [PDF]

Epigenomics
Aim We compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups.
Merbaum P, Zwamborn R, Hop P, Sequencing Consortium PMA, van Rheenen W, Veldink J.   +5 more
europepmc   +2 more sources

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Frontiers in Medicine, 2022
Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos, Bernardo Lemos   +5 more
doaj   +1 more source

Mitochondrial Dysfunction Accelerates Ageing

Immunometabolism, 2020
Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire   +3 more sources

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
doaj   +1 more source

Epigenetic age acceleration and psychosocial stressors in early childhood. [PDF]

Epigenomics
The impact of psychosocial stress on mental and physical health is well-documented. Adverse experiences that occur early in life are particularly impactful on later life health.
Mulligan CJ.
europepmc   +2 more sources

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance In a nationally representative US adult population, measures of epigenetic age acceleration are associated with concurrent cognitive dysfunction, functional limitations and chronic conditions measured 2 y after DNA methylation measurement ...
J. Faul, J. K. Kim, M. Levine, B. Thyagarajan, D. Weir, E. Crimmins   +5 more
semanticscholar   +1 more source

DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D

Biomedicines, 2020
Type 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic ...
Raúl F Pérez, Juan Luis Fernandez-Morera, Judit Romano-Garcia, Edelmiro Menendez-Torre, Elias Delgado-Alvarez, Mario F Fraga, Agustin F Fernandez   +6 more
doaj   +1 more source