Results 21 to 30 of about 9,776,047 (207)

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Frontiers in Aging Neuroscience, 2021
Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking.
Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin, Luigi Ferrucci   +4 more
doaj   +1 more source

Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell‐type deconvolution applied to human blood epigenetic clocks

Aging Cell, 2023
Aging is a significant risk factor for various human disorders, and DNA methylation clocks have emerged as powerful tools for estimating biological age and predicting health‐related outcomes.
Ze Zhang, Samuel R Reynolds, Hannah G. Stolrow, Ji-Qing Chen, B. Christensen, L. Salas   +5 more
semanticscholar   +1 more source

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging.
Lili Xiao, Gaohui Zan, Chaoqun Liu, Xia Xu, Longman Li, Xing Chen, Zhiyong Zhang, Xiaobo Yang   +7 more
doaj   +1 more source

The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)

Aging Cell, 2023
Research examining the association between exposure to a wide range of adverse childhood experiences (ACEs) and accelerated biological aging in older adults is limited.
Divya Joshi, Andrea Gonzalez, D. Lin, P. Raina   +3 more
semanticscholar   +1 more source

Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease

Clinical Epigenetics, 2023
Background DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with coronary heart disease (CHD ...
J. Si, Lu Chen, Canqing Yu, Yu Guo, D. Sun, Y. Pang, I. Millwood, R. Walters, Ling Yang, Yiping Chen, H. Du, Shixian Feng, Xiaoming Yang, D. Avery, Junshi Chen, Zhengming Chen, L. Liang, Liming Li, J. Lv, Junshi Zhengming Rory Liming Richard Daniel Ruth Derrick Chen Chen Collins Li Peto Avery Boxall Bennett Cha, Junshi Chen, Zhengming Chen, R. Collins, Liming Li, R. Peto, D. Avery, Ruth Boxall, D. Bennett, Yumei Chang, Yiping Chen, R. Clarke, H. Du, S. Gilbert, A. Hacker, Michael V Holmes, A. Iona, C. Kartsonaki, R. Kerosi, Ling Kong, Om P Kurmi, G. Lancaster, S. Lewington, Kuang Lin, J. McDonnell, W. Mei, I. Millwood, Qunhua Nie, J. Radhakrishnan, Sajjad Rafiq, Paul Ryder, S. Sansome, D. Schmidt, P. Sherliker, Rajani Sohoni, I. Turnbull, R. Walters, Jenny T. Wang, Lin Wang, Ling Yang, Xiaoming Yang, Z. Bian, Ge Chen, Yu Guo, C. Hou, J. Lv, P. Pei, Shuzhen Qu, Yunlong Tan, Canqing Yu, Z. Pang, R. Gao, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, X. Tian, Hua Zhang, Silu Lv, Junzheng Wang, W. Hou, Jiyuan Yin, G. Jiang, Xue Zhou, Liqiu Yang, Hui He, Bo Yu, Yanjie Li, H. Mu, Qinai Xu, Meiling Dou, Jiaojiao Ren, Shanqing Wang, Ximin Hu, Hongmei Wang, Jinyan Chen, Yan Fu, Z. Fu, Xiaohuan Wang, M. Weng, Xiangyang Zheng, Yilei Li, Huimei Li, Yanjun Wang, Ming Wu, Jinyi Zhou, R. Tao, Jie Yang, Chuanming Ni, Jun Zhang, Yi-Heng Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jing-chao Liu, Zhen-zhu Tang, N. Chen, Ying Huang, Mingqiang Li, Jinhuai Meng, R. Pan, Qilian Jiang, Weiyuan Zhang, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Hairong Guan, Xian-ping Wu, Ningmei Zhang, Xiaofang Chen, Xuefeng Tang, G. Luo, Jianguo Li, X. Zhong, Jiaqiu Liu, Qian Sun, Peng-fei Ge, X. Ren, C. Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Ding Zhang, G. Zhou, Shixian Feng, Liang Chang, L. Fan, Yulian Gao, Tianyou He, Huarong Sun, P. He, Chen Hu, Qiannan Lv, Xukui Zhang, Min Yu, R. Hu, Hao Wang, Y. Qian, Chunmei Wang, K. Xie, Lingli Chen, Yidan Zhang, D. Pan, Yuelong Huang, Biyun Chen, Lina Yin, D. Jin, Hui-lin Liu, Z. Fu, Qiaohua Xu, Xin Xu, Hao Zhang, Youping Xiong, Huajun Long, Xianzhi Li, Libo Zhang, Zhe Qiu   +181 more
semanticscholar   +1 more source

Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life

The journals of gerontology. Series A, Biological sciences and medical sciences, 2023
DNA methylation-derived epigenetic clocks offer the opportunity to examine aspects of age acceleration (ie, the difference between an individual’s biological age and chronological age), which vary among individuals and may better account for age-related ...
Daisy V Zavala, Natalie Dzikowski, Shyamalika Gopalan, Karra D Harrington, Giancarlo Pasquini, Jacqueline A Mogle, Kerry Reid, Martin J Sliwinski, Jennifer E. Graham-Engeland, C. Engeland, Kristin Bernard, Krishna Veeramah, Stacey B. Scott   +12 more
semanticscholar   +1 more source

Obesity accelerates thymic aging

Blood, 2009
Abstract As the expanding obese population grows older, their successful immunologic aging will be critical to enhancing the health span. Obesity increases risk of infections and cancer, suggesting adverse effects on immune surveillance.
Hyunwon, Yang, Yun-Hee, Youm, Bolormaa, Vandanmagsar, Jennifer, Rood, K Ganesh, Kumar, Andrew A, Butler, Vishwa Deep, Dixit   +6 more
openaire   +3 more sources

Failure of immunosurveillance accelerates aging [PDF]

OncoImmunology, 2019
Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs ...
Maria Perez-Lanzon, Laurence Zitvogel, Guido Kroemer   +2 more
openaire   +4 more sources

Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation

Epigenetics, 2023
Prenatal maternal stress has a negative impact on child health but the mechanisms through which maternal stress affects child health are unclear. Epigenetic variation, such as DNA methylation, is a likely mechanistic candidate as DNA methylation is ...
Edward B. Quinn, Chu J. Hsiao, F. Maisha, C. Mulligan   +3 more
semanticscholar   +1 more source

Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Environment International, 2023
Introduction: Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based “
Kaila Boyer, Arce Domingo-Relloso, Enoch Jiang, Karin Haack, Walter Goessler, Ying Zhang, Jason G. Umans, Daniel W. Belsky, Shelley A. Cole, Ana Navas-Acien, Allison Kupsco   +10 more
doaj   +1 more source