Results 31 to 40 of about 9,776,047 (207)

Obesity and Accelerated Aging

The Journal of nutrition, health and aging, 2023
Abstract Obesity in the older population has increased in prevalence and incidence over the last several decades and has been associated with a decline in physical function, quality of life, and increased risk of complications from cardiometabolic diseases. Several interrelated hallmarks of aging have been proposed.
openaire   +1 more source

Subfertility reflects accelerated ovarian ageing [PDF]

Human Reproduction, 2003
The aim of the study was to explore the extent to which accelerated ovarian ageing may lead to subfertility early in reproductive life and eventually cause early menopause.The population studied (n = 2393) never used oral contraceptives, hormone replacement therapy or an intrauterine device.
Kok, Helen S., van Asselt, Kristel M., van der Schouw, Yvonne T., Grobbee, Diederick E., te Velde, Egbert R., Pearson, Peter L., Peeters, Petra H. M.   +6 more
openaire   +3 more sources

Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study

Clinical Epigenetics, 2023
Background Epigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health outcomes.
Zhihao Wang, Yi Liu, Shuxin Zhang, Yu-ru Yuan, Siliang Chen, Wenhao Li, Mingrong Zuo, Yufan Xiang, Tengfei Li, Wanchun Yang, Yuan Yang, Yanhui Liu   +11 more
semanticscholar   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Ya-Feng Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, A. Anderson, J. Lash, T. Kelly   +7 more
semanticscholar   +1 more source

Investigating the Relationship between Epigenetic Age and Cardiovascular Risk in a Population with Overweight/Obesity

Biomedicines
Introduction: Cardiovascular diseases stand as the leading global cause of mortality. Major modifiable risk factors encompass overweight/obese conditions, high blood pressure, elevated LDL cholesterol, diabetes, smoking, secondhand smoke exposure ...
Davide Marinello, Chiara Favero, Benedetta Albetti, Davide Barbuto, Luisella Vigna, Angela Cecilia Pesatori, Valentina Bollati, Luca Ferrari   +7 more
doaj   +1 more source

How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies

Cardiovascular Diabetology
Recent basic biological research found that obesity accelerates biological aging and increases cardiovascular disease (CVD) risk. However, there is still a lack of real-world population evidence.
Lin Hu, Jiayuan Li, Zihuan Tang, Peng Gong, Zongqi Chang, Chen Yang, Tianpei Ma, Shuang Jiang, Chunxia Yang, Tao Zhang   +9 more
semanticscholar   +1 more source

Alcohol consumption and epigenetic age acceleration across human adulthood

Aging, 2023
The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses to investigate the associations between alcohol consumption and two DNA methylation-based biological age acceleration metrics in 3823 ...
Mengyao Wang, Yi Li, M. Lai, D. Nannini, Lifang Hou, R. Joehanes, T. Huan, Daniel Levy, Jiantao Ma, Chunyu Liu   +9 more
semanticscholar   +1 more source

Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration

Environment International, 2023
Climate change poses a serious threat to human health worldwide, while aging populations increase. However, no study has ever investigated the effects of air temperature on epigenetic age acceleration.
Wenli Ni, Nikolaos Nikolaou, Cavin K. Ward-Caviness, Susanne Breitner, Kathrin Wolf, Siqi Zhang, Rory Wilson, Melanie Waldenberger, Annette Peters, Alexandra Schneider   +9 more
doaj   +1 more source

Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations.

Ageing Research Reviews
Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing.
O. Chervova, Kseniia Panteleeva, Elizabeth Chernysheva, Tyas Arum Widayati, Žan Florjanic Baronik, Natalie Hrbkova, Jadesada Schneider, M. Bobák, Stephan Beck, V. Voloshin   +9 more
semanticscholar   +1 more source

Associations between prenatal phthalate exposure and childhood epigenetic age acceleration.

Environmental Research, 2023
BACKGROUND Phthalates, a group of pervasive endocrine-disrupting chemicals found in plastics and personal care products, have been associated with a wide range of developmental and health outcomes.
D. Khodasevich, N. Holland, A. Hubbard, K. Harley, J. Deardorff, B. Eskenazi, Andres Cardenas   +6 more
semanticscholar   +1 more source