Results 41 to 50 of about 9,776,047 (207)

Biological Aging and Chemotoxicity in Patients with Colorectal Cancer: A Secondary Data Analysis Using EHR Data

Current Oncology
Background: Biological aging influences cancer outcomes, but its changes during chemotherapy and impact on chemotoxicity in colorectal cancer (CRC) remain underinvestigated.
Claire J. Han, Ashley E. Rosko, Jesse J. Plascak, Alai Tan, Anne M. Noonan, Christin E. Burd   +5 more
doaj   +1 more source

Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis

Neurology, 2023
Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune system (immunosenescence) may be associated with disease onset or drive progression.
V. Maltby, A. Xavier, Ewoud Ewing, M. Campagna, S. Sampangi, R. Scott, H. Butzkueven, V. Jokubaitis, L. Kular, S. Bos, M. Slee, I. van der Mei, B. Taylor, A. Ponsonby, M. Jagodic, R. Lea, J. Lechner-Scott   +16 more
semanticscholar   +1 more source

Gender disparities in marital status and risk of developing age acceleration: Findings from NHANES 2015–2018

Experimental Gerontology
Background: Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging.
Jialu Wang, Feixiang Xu, Yin Wang, Lizhan Bie   +3 more
doaj   +1 more source

Parenting Practices May Buffer the Impact of Adversity on Epigenetic Age Acceleration Among Young Children With Developmental Delays

Psychology Science, 2023
This study examined whether children exposed to adversity would exhibit lower epigenetic age acceleration in the context of improved parenting. Children with developmental delays and externalizing behavior problems (N = 62; Mage = 36.26 months; 70.97 ...
A. Sullivan, A. Bozack, Andres Cardenas, Jonathan S. Comer, D. Bagner, Rex Forehand, J. Parent   +6 more
semanticscholar   +1 more source

Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

Neuropsychopharmacology, 2023
Different psychiatric disorders as well as exposure to adverse life events have individually been associated with multiple age-related diseases and mortality.
Natan Yusupov, L. Dieckmann, Mira Erhart, S. Sauer, M. Rex-Haffner, J. Kopf-Beck, T. Brückl, D. Czamara, E. Binder   +8 more
semanticscholar   +1 more source

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

Epigenetic age acceleration and clinical outcomes in gliomas.

PLoS ONE, 2020
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas.
Chunlei Zheng, Nathan A Berger, Li Li, Rong Xu   +3 more
doaj   +1 more source

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports, 2020
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age.
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus   +12 more
doaj   +1 more source

The early-life exposome and epigenetic age acceleration in children

Environment International, 2021
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood
Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina Vafeiadi, Jordi Sunyer, Martine Vrijheid, Mariona Bustamante   +25 more
doaj   +1 more source

The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target.

Environment International
INTRODUCTION Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, the mixed effect of multiple types of EDCs on biological age ...
Weichao Huang, Zilong Zhang, Manuel Colucci, L. Deng, Mi Yang, Xinyi Huang, Xianghong Zhou, Yumin Jin, E. Lazzarini, C. Balbi, Juanola Juarez Oriol, Aurora Valdata, Silvia Bressan, Y. Zhan, Fang Qi, Qiang Wei, Lu Yang, Xiaoli Zou, Shi Qiu   +18 more
semanticscholar   +1 more source