Results 51 to 60 of about 9,776,047 (207)

DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease

GeroScience, 2023
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence of NAFLD has been increasing with aging for unknown reasons.
Mingfeng Xia, Wenran Li, Huan-Dong Lin, Hailuan Zeng, Shuai Ma, Qi Wu, Hui Ma, Xiaoming Li, Bai-shen Pan, Jian Gao, Yu Hu, Yun Liu, Sijia Wang, Xin Gao   +13 more
semanticscholar   +1 more source

Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions

Biology
The exposome, which encompasses lifetime environmental exposures, significantly impacts health and can act as a major driving force in accelerating the aging process.
Anna E. Kallio, Ekaterina A. Davydova, Tatiana A. Mishchenko, Tatiana M. Sivtseva, Maria M. Nikolaeva, Dmitriy E. Burmistrov, Anzhela D. Bolshakova, Sergey N. Tsybusov, Raisa N. Zakharova, Maria V. Vedunova   +9 more
doaj   +1 more source

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis

EBioMedicine, 2019
Background: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes.
Xiaoyu Li, Roby Joehanes, Ina Hoeschele, Stephen S. Rich, Jerome I. Rotter, Daniel Levy, Yongmei Liu, Susan Redline, Tamar Sofer   +8 more
doaj   +1 more source

DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While DNA methylation (DNAm)‐based algorithms of aging show promise for predicting age‐related diseases, their comparative utility for incident cardiovascular disease (CVD) remains underexplored.
Xian Cui, Chunbei Yi, Hui Zhang, Yaqian Xu, Chongyu Ding, Zhaojun Wang, Shiqun Sun, Xiangwei Li   +7 more
doaj   +1 more source

Obesity May Accelerate the Aging Process [PDF]

Frontiers in Endocrinology, 2019
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world ...
Salvestrini V., Sell C., Lorenzini A.
openaire   +3 more sources

Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.

Social Science & Medicine (1967), 2023
An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older adults having greater risk. Like other age-related diseases, residents of high-deprivation neighborhoods experience worse KOA pain outcomes compared to their more
Pamela Jackson, Antoinette L. Spector, L. Strath, Lisa H. Antoine, Peng Li, B. Goodin, Bertha Hidalgo, M. Kempf, Cesar E. Gonzalez, Alana C. Jones, T. Foster, Jessica A. Peterson, T. Quinn, Zhiguang Huo, R. Fillingim, Y. Cruz-Almeida, Edwin N. Aroke   +16 more
semanticscholar   +1 more source

Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE‐T Cohort

Journal of Cachexia, Sarcopenia and Muscle
Background Biological clocks are promising tools for the evaluation of biological age deviations (i.e., positive/negative acceleration). Here, we explored the associations of biological age acceleration (BAA) assessed by Horvath's, Hannum's, PhenoAge ...
Juan Luis Sánchez‐Sánchez, Bruno Vellas, Sophie Guyonnet, Paul Bensadoun, Jean‐Marc Lemaitre, Matias Fuentealba Valenzuela, Fabien Pillard, Yves Rolland, David Furman, Philipe deSouto Barreto   +9 more
doaj   +1 more source

Anxiety disorders and accelerated cellular ageing [PDF]

British Journal of Psychiatry, 2015
BackgroundAnxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing.AimsTo examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing.MethodData are from individuals with current (n = 1283) and ...
Verhoeven, Josine E., Revesz, Dora, van Oppen, Patricia, Epel, Elissa S., Wolkowitz, Owen M., Penninx, Brenda W.   +5 more
openaire   +5 more sources

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

medRxiv, 2023
Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan.
F. Torma, C. Kerepesi, Mátyás Jókai, Gergely Babszki, E. Koltai, B. Ligeti, R. Kalcsevszki, Kristen M. McGreevy, S. Horvath, Z. Radák   +9 more
semanticscholar   +1 more source

DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

Acta Neuropathologica Communications, 2022
Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis.
Pierre Bady, Christine Marosi, Michael Weller, Bjørn H. Grønberg, Henrik Schultz, Martin J. B. Taphoorn, Johanna M. M. Gijtenbeek, Martin J. van den Bent, Andreas von Deimling, Roger Stupp, Annika Malmström, Monika E. Hegi   +11 more
doaj   +1 more source