Results 61 to 70 of about 9,776,047 (207)
Mechanical Deformation Accelerates Protein Ageing
Angewandte Chemie, 2017 AbstractA hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile
Jessica Valle‐Orero +6 more
openaire +4 more sources
Social disadvantage accelerates aging
Nature MedicineAbstract Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases.
Kivimäki, M +11 more
openaire +3 more sources
Age-Specific Acceleration of Cancer [PDF]
Current Biology, 2004 One of the great challenges of cancer research is to explain the epidemiological patterns of cancer incidence based on the molecular processes that lead to uncontrolled cellular proliferation. The epidemiological data demonstrate that the age-specific incidence of many cancers increases in an approximately linear way with age when plotted on a log-log ...
openaire +2 more sources
Longitudinal Changes in Epigenetic Age Acceleration Across Childhood and Adolescence
JAMA pediatricsKey Points Question Does epigenetic age acceleration change as youths transition from childhood to adolescence, do these changes in epigenetic age acceleration differ between youths from diverse ethnic and racial backgrounds, and do interpersonal ...
J. Del Toro +7 more
semanticscholar +1 more source
DNA methylation age acceleration is associated with risk of diabetes complications
Communications Medicine, 2023 Patients with Type 2 diabetes mellitus (T2D) are at risk for micro- and macrovascular complications. Implementable risk scores are needed to improve targeted prevention for patients that are particularly susceptible to complications. The epigenetic clock
V. Vetter +7 more
semanticscholar +1 more source
Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age
Clinical Epigenetics, 2023 Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse ...
Drew R. Nannini +4 more
doaj +1 more source
Epigenetics, 2023 Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk
Uriel Paniagua +15 more
doaj +1 more source
Age and AgeingBackground Epigenetic ageing is among the most promising ageing biomarkers and may be a useful marker of physical function decline, beyond chronological age.
Aung Zaw Zaw Phyo +6 more
semanticscholar +1 more source
Probabilistic inference of epigenetic age acceleration from cellular dynamics
bioRxiv, 2023 The emergence of epigenetic predictors was a pivotal moment in geroscience, propelling the measurement and concept of biological ageing into a quantitative era.
Jan. K. Dabrowski +8 more
semanticscholar +1 more source
bioRxiv, 2023 Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui +8 more
semanticscholar +1 more source