Results 71 to 80 of about 814,837 (335)

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Local Order in the Unfolded State: Conformational Biases and Nearest Neighbor Interactions

Biomolecules, 2014
The discovery of Intrinsically Disordered Proteins, which contain significant levels of disorder yet perform complex biologically functions, as well as unwanted aggregation, has motivated numerous experimental and theoretical studies aimed at describing ...
Siobhan Toal, Reinhard Schweitzer-Stenner   +1 more
doaj   +1 more source

Fluctuation Effects of Magnetohydrodynamic Micro-Vortices on Odd Chirality in Magnetoelectrolysis

Magnetochemistry, 2020
The magnetic field dependence of chiral surface formation was investigated in magnetoelectrodeposition (MED) and magnetoelectrochemical etching (MEE) of copper films.
Iwao Mogi, Ryoichi Aogaki, Kohki Takahashi   +2 more
doaj   +1 more source

High-pressure Raman study of L-alanine crystal

, 2000
Pressure-dependent Raman scattering studies in the range 0.0 -- 32 kbar were carried out in L-alanine in order to investigate its external mode phonon spectra in relation to the phase transitions in the crystal.
A.J.D. Moreno, A.M.R. Teixeira, A.P. Ayala, Adamowicz, F.E.A. Melo, Forss, J. Mendes Filho, J.M. Sasaki, Jackson, Jonsson, Kwok, Lemanov, Loh, Machida, Migliori, Moreno, P.T.C. Freire, Ramanadham, Shoemaker, Silva, Simpson, Wang   +21 more
core   +2 more sources

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. [PDF]

, 2013
Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway.
Bao, Ju, Carroll, Candace E, Grace, Christy RR, Guibao, Cristina D, Lee, Ho-Jin, Marada, Suresh, Ogden, Stacey K, Rana, Rajashree, Zheng, Jie J   +8 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility

Frontiers in Physics
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standards are lacking.
Vilde F. Rieker, Vilde F. Rieker, Joseph J. Bateman, Laurence Wroe, Misael Caloz, Veljko Grilj, Ygor Q. Aguiar, Andreas Schüller, Claude Bailat, Wilfrid Farabolini, Antonio Gilardi, Cameron Robertson, Pierre Korysko, Pierre Korysko, Alexander Malyzhenkov, Steinar Stapnes, Steinar Stapnes, Marie-Catherine Vozenin, Manjit Dosanjh, Manjit Dosanjh, Roberto Corsini   +20 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source