Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: evidence from discordant monozygotic twins [PDF]
Although a higher protein intake, particularly from vegetable sources, has been shown to be associated with higher bone mineral density (BMD) the relative impact of specific amino acids (AA) on BMD and risk of osteoporosis remains to be determined ...
Ammann+45 more
core +1 more source
Markerless Mutagenesis inMethanococcus maripaludisDemonstrates Roles for Alanine Dehydrogenase, Alanine Racemase, and Alanine Permease [PDF]
ABSTRACTAmong the archaea,Methanococcus maripaludishas the unusual ability to usel- ord-alanine as a nitrogen source. To understand how this occurs, we tested the roles of three adjacent genes encoding homologs of alanine dehydrogenase, alanine racemase, and alanine permease.
John A. Leigh, Brian C. Moore
openaire +3 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Chiral Symmetry Breaking in Magnetoelectrochemical Etching with Chloride Additives
Magnetoelectrolysis (electrolysis under magnetic fields) produces chiral surfaces on metal thin films, which can recognize the enantiomers of amino acids.
Iwao Mogi+2 more
doaj +1 more source
Changes in alanine aminotransfearase, aspartate aminotransfearase in blasma, kidney and liver in rabbits treated with cadmium chloride [PDF]
The study was designed to investigate the subchronic toxic effect of cadmium chloride administered orally on alanine aminotransfearase (ALT), aspartate aminotransfearase (AST) activity and certain tissues in adult male rabbits.
K. A. Mohi-Aldeen
doaj +1 more source
Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W.+5 more
core +2 more sources
Interaction Entropy for Computational Alanine Scanning
The theoretical calculation of protein-protein binding free energy is a grand challenge in computational biology. Accurate prediction of critical residues along with their specific and quantitative contributions to protein-protein binding free energy is ...
Yuna Yan+3 more
semanticscholar +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Study of the chemical evolution and spectral signatures of some interstellar precursor molecules of adenine, glycine alanine [PDF]
We carry out a quantum chemical calculation to obtain the infrared and electronic absorption spectra of several complex molecules of the interstellar medium (ISM). These molecules are the precursors of adenine, glycine & alanine. They could be produced in the gas phase as well as in the ice phase.
arxiv +1 more source
While spent catalysts can cause serious environmental pollution, they can be considered an essential secondary metal source due to their high critical metal grades.
Idol Phann+3 more
doaj +1 more source