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Critical and diverse role of alarmin cytokines in parasitic infections [PDF]

Frontiers in Cellular and Infection Microbiology
Alarmin cytokines including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) function as danger signals to trigger host immunity in response to tissue injury caused by pathogenic factors such as parasitic infections.
Zhou Xing, Suiyi Liu, Xing He
doaj +2 more sources

Potential of alarmin-targeted bispecific and combination therapies in airway disease [PDF]

Frontiers in Allergy
Thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
doaj +2 more sources

Epithelial-derived cytokines in the pathogenesis of severe asthma [PDF]

Frontiers in Allergy
IntroductionAirway epithelial cells function as the first physical barrier against pathogens and are key regulators of immune responses by producing a wide array of cytokines involved in both innate and adaptive immunity.MethodsThis review summarizes ...
Duong Duc Pham, Tae-Bum Kim
doaj +2 more sources

HMGB-1 in Psoriasis

Biomolecules, 2021
Psoriasis is a multifactorial pathology linked to systemic inflammation. Enhanced keratinocytes proliferation and a minor maturation state of the cells are typical features.
Marco Casciaro, Eleonora Di Salvo, Sebastiano Gangemi +2 more
doaj +1 more source

Association between Serum Levels of Interleukin-25/Thymic Stromal Lymphopoietin and the Risk of Exacerbation of Chronic Obstructive Pulmonary Disease

Biomolecules, 2023
Th2 inflammation is associated with various characteristics of patients with chronic obstructive pulmonary disease (COPD). In this study, we analyzed the COPD exacerbation risk associated with serum levels of interleukin (IL)-25/thymic stromal ...
Joon Young Choi +9 more
doaj +1 more source

Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes

Advanced Science, 2022
Mechanisms keeping leukocytes distant of local inflammatory processes in a resting state despite systemic release of inflammatory triggers are a pivotal requirement for avoidance of overwhelming inflammation but are ill defined.
Antonella Russo +19 more
doaj +1 more source

IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity

Cells, 2021
Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the nuclei of endothelial and epithelial cells of barrier tissues, among others.
Corinne Cayrol
doaj +1 more source

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation

Cells, 2020
Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases.
Nina D. Anfinogenova +3 more
doaj +1 more source

The Role of Interleukin-33 in Head and Neck Squamous Cell Carcinoma Is Determined by Its Cellular Sources in the Tumor Microenvironment

Frontiers in Oncology, 2021
ObjectivesTo investigate the role of interleukin-33 (IL-33) in head and neck squamous cell carcinoma (HNSCC).Materials and MethodsRNA-seq data of 520 cases of HNSCC were retrieved from The Cancer Genome Atlas. The tumor microenvironment was deconstructed
Liang Peng +8 more
doaj +1 more source

The GAR/RGG motif defines a family of nuclear alarmins

Cell Death and Disease, 2021
The nucleus is the target of autoantibodies in many diseases, which suggests intrinsic nuclear adjuvants that confer its high autoimmunogenicity. Nucleolin (NCL) is one abundant nucleolar autoantigen in systemic lupus erythematosus (SLE) patients and, in
Shan Wu +4 more
doaj +1 more source

il-33
inflammation
tslp

hmgb1
asthma
il-25

psoriasis
interleukin-33
st2