Results 11 to 20 of about 13,748 (218)
Medicina, 2022 Schizophrenia, consisting of a group of severe psychiatric disorders with a complex etiology, is a leading cause of disability globally. Due to the lack of objective indicators, accurate diagnosis and selection of effective treatments for schizophrenia remain challenging.
Huan Ma, Ning Cheng, Caiyi Zhang
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Immunological Reviews, 2017 SummaryMore than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host ...
De Yang, Zhen Han, Joost J. Oppenheim
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Alarmins, COVID-19 and comorbidities [PDF]
Annals of Medicine, 2021 The coronavirus SARS-CoV-2, the aetiological agent of COVID-19 disease, is representing a worldwide threat for the medical community and the society at large so that it is being defined as "the twenty-first-century disease". Often associated with a severe cytokine storm, leading to more severe cases, it is mandatory to block such occurrence early in ...
Di Salvo E. +4 more
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Nuclear Alarmin Cytokines in Inflammation [PDF]
Journal of Immunology Research, 2020 Pathogen‐associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response.
Lili Jiang +4 more
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Alarmins and antimicrobial immunity [PDF]
Medical Mycology, 2009 Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of ...
D, Yang, J J, Oppenheim
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Full length interleukin 33 aggravates radiation-induced skin reaction [PDF]
, 2017 The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Adam, Susanne +13 more
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Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions
Cells, 2022 Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine, plays critical roles in maintaining host homeostasis and in pathological conditions, such as allergy, infectious diseases, and cancer, by acting on multiple ...
Han Guo +4 more
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Alarmins and Antitumor Immunity [PDF]
Clinical Therapeutics, 2016 Alarmins are constitutively present endogenous molecules that essentially act as early warning signals for the immune system. We provide a brief overview of major alarmins and highlight their roles in tumor immunity.We searched PubMed up to January 10, 2016, using alarmins and/or damage-associated molecular patterns (DAMPs), as key words.
Yingjie, Nie +2 more
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Frontiers in Immunology, 2023 Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response ...
Valentina Carlini +7 more
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Sounding the alarmins—The role of alarmin cytokines in asthma
Allergy, 2022 AbstractThe alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2
Gail M. Gauvreau +9 more
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