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Alarmins: Feel the Stress [PDF]
The Journal of Immunology, 2017 Abstract Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the “danger hypothesis,” it was recently shown that alarmins can also directly ...
Rider, P. +5 more
openaire +2 more sources
TSLP and asthma: fellow travelers [PDF]
Exploration of Asthma & Allergy, 2023 The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj +1 more source
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review
Medicina, 2019 Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues.
Alessandro Tonacci +2 more
doaj +1 more source
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
core +1 more source
Alarmin‐induced cell migration [PDF]
European Journal of Immunology, 2013 Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the induction of innate and adaptive immune responses. For our immune system to function appropriately, it relies on navigating various leukocytes to distinct places at the right time.
De, Yang +4 more
openaire +2 more sources
Frontiers in Immunology, 2023 Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT ...
Aurélie Robin +11 more
doaj +1 more source
Alarmins from conjunctival fibroblasts up-regulate matrix metalloproteinases in corneal fibroblasts [PDF]
International Journal of Ophthalmology, 2020 AIM: To explore the effects of alarmins produced by necrotic human conjunctival fibroblasts on the release of matrix metalloproteinases (MMPs) by human corneal fibroblasts (HCFs).
Lin Chen +6 more
doaj +1 more source
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease [PDF]
, 2015 MicroRNA (miRNA) has the potential for cross-regulation and functional integration of discrete biological processes during complex physiological events.
Akbar, Moeed +9 more
core +1 more source
Tumor necrosis factor is a necroptosis-associated alarmin
Frontiers in Immunology, 2022 Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis can lead to strong inflammatory responses, little is known about the identity of the ...
Francesca Pinci +5 more
doaj +1 more source