Results 31 to 40 of about 13,748 (218)

Alarmins in frozen shoulder: a molecular association between inflammation and pain [PDF]

, 2017
Background: The pathophysiological mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear.
Akbar, Moeed, Cher, Jonathon Z.B., Crowe, Lindsay A.N., Fazzi, Umberto G., Garcia-Melchor, Emma, Hannah, Stephen C., Kerr, Shauna C., Kitson, Susan, McLean, Michael, Millar, Neal L., Murrell, George A.C.   +10 more
core   +1 more source

Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation

Frontiers in Immunology, 2021
Ischemia and reperfusion injury is an early inflammatory process during liver transplantation that impacts on graft function and clinical outcomes. Interleukin (IL)-33 is a danger-associated molecular pattern involved in kidney ischemia/reperfusion ...
Louise Barbier, Louise Barbier, Louise Barbier, Louise Barbier, Aurélie Robin, Aurélie Robin, Aurélie Robin, Rémy Sindayigaya, Rémy Sindayigaya, Rémy Sindayigaya, Rémy Sindayigaya, Héloïse Ducousso, Héloïse Ducousso, Héloïse Ducousso, Héloïse Ducousso, Fanny Dujardin, Antoine Thierry, Antoine Thierry, Antoine Thierry, Antoine Thierry, Antoine Thierry, Thierry Hauet, Thierry Hauet, Thierry Hauet, Thierry Hauet, Thierry Hauet, Jean-Philippe Girard, Luc Pellerin, Luc Pellerin, Luc Pellerin, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, André Herbelin, André Herbelin, André Herbelin, Ephrem Salamé, Ephrem Salamé, Ephrem Salamé, Ephrem Salamé   +41 more
doaj   +1 more source

Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis

Frontiers in Immunology, 2019
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to ...
Karen Dubois-Camacho, David Diaz-Jimenez, David Diaz-Jimenez, Marjorie De la Fuente, Marjorie De la Fuente, Rodrigo Quera, Daniela Simian, Maripaz Martínez, Glauben Landskron, Mauricio Olivares-Morales, John A. Cidlowski, Xiaojiang Xu, Guangping Gao, Jun Xie, Jonás Chnaiderman, Ricardo Soto-Rifo, María-Julieta González, Andrea Calixto, Andrea Calixto, Marcela A. Hermoso   +19 more
doaj   +1 more source

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons [PDF]

, 2017
The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders.
Alhouayek M, Amor S, Amor S, Appel SH, Bankston AN, Biber K, Biran V, Borsook D, Brenner T, Brooks TA, Buchanan MM, Bulanova E, Burnstock G, Calcia MA, Castellheim A, Chan-Ling T, Chen YJ, Choudhuri K, Christophi GP, Christy AL, Compston A, Conti P, Corrigan F, Cristino L, Cunningham C, Dirckx M, Donath MY, Done JD, D’Agostino G, Eckenhoff RG, Eggen BJ, Ellis A, Engler H, Ertürk A, Eskander MA, Esposito P, Fonken LK, Forsythe P, Freeman LC, Fullerton JN, Gao YJ, Gaudenzio N, Geppetti P, Grace PM, Grakoui A, Gregory GD, Griffin RS, Guerreiro R, Gunin AG, Hagiyama M, Hains LE, Hanisch UK, Harcha PA, Harvey GK, Hayashi R, Heneka MT, Hickman SE, Hsieh CL, Hu W, Héron A, Iadecola C, Ito A, Jay GW, Jensen TS, Ji RR, Jin Y, Jin Y, Juremalm M, Kajihara Y, Kalesnikoff J, Kalichman MW, Kamm CP, Kerstman E, Kobayashi K, Kolbinger F, Koshinaga M, Kwon C, Lange C, Lapilover EG, Laura Facci, Le Thuc O, Leon A, Levy D, Li M, Li X, Liew FY, Lozada A, Lull ME, Luongo L, Manocha GD, Marchi N, Martini R, Maslinska D, Mate I, Matsuda H, Mattila OS, McGeer PL, Medeiros R, Medic N, Medic N, Michaloudi H, Michaud M, Millan MJ, Miller G, Milligan ED, Monks CR, Morena Zusso, Myers RR, Nakae S, Nakajima A, Nathan C, Nave KA, Nelissen S, Nguyen M, Norden DM, Noriega DB, Old EA, Orr AG, Osipchuk Y, Osterberg A, Park CK, Parvathenani LK, Patti GJ, Peferoen L, Peferoen LA, Pekny M, Pelisch N, Perry VH, Perry VH, Pietro Giusti, Prinz M, Prussin C, Punzo D, Ramlackhansingh AF, Ransohoff RM, Rapp JH, Rawji KS, Riedel B, Rivat C, Rosa AC, Sakamoto A, Sastre M, Sayed BA, Silver R, Silverman AJ, Sivanandam TM, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skuljec J, Smith BH, Smith JA, Sospedra M, Stephen D. Skaper, Streit WJ, Suurmond J, Terrando N, Thacker MA, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Ulmann L, van Hecke O, Varma R, von Büdingen HC, Vyas H, Wang M, Wang Y, Wardlaw AJ, Watkins LR, Wohleb ES, Xie F, Young KM, Yuan H, Zarpelon AC, Zeis T, Zhang H, Zhang S, Zhang ZG, Zuo Y   +183 more
core   +1 more source

Tumors Sound the Alarmin(s) [PDF]

Cancer Research, 2008
Abstract Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology.
Seth B, Coffelt, Aline B, Scandurro
openaire   +2 more sources

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

Frontiers in Immunology, 2012
During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival and to induce pro-angiogenic factors. Hypoxia induced factors (HIFs) regulate these transcriptional alterations.
Peleg eRider, Irena eKaplanov, Marianna eRomzova, Liora eBernardis, Alex eBraiman, Elena eVoronov, Ron Nathan Apte   +6 more
doaj   +1 more source

Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]

, 2016
Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie, Barnett, Susan C., Elliott, Christina, Fairlie-Clarke, Karen J., Jiang, Hui-Rong, Lassmann, Hans, Linnington, Christopher, Schuh, Cornelia   +7 more
core   +2 more sources

Do advanced glycation end products contribute to food allergy?

Frontiers in Allergy, 2023
Sugars can bind non-enzymatically to proteins, nucleic acids or lipids and form compounds called Advanced Glycation End Products (AGEs). Although AGEs can form in vivo, factors in the Western diet such as high amounts of added sugars, processing methods ...
P. K. Smith, C. Venter, L. O’Mahony, R. Berni Canani, O. J. L. Lesslar   +4 more
doaj   +1 more source