Results 51 to 60 of about 13,748 (218)

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation [PDF]

, 2018
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular
A Dixit, A Jäger, A Tanay, A Wagner, AK Björklund, Antonia Wallrapp, Aviv Regev, BD Modena, Brian J. Haas, Bruce D. Levy, C Soneson, CE Prendergast, Christoph S. N. Klose, Christopher Rodman, D Cheng, Daneyal Farouq, Danielle Dionne, David Artis, DF Gudbjartsson, DR Neill, F Gerbe, GX Zheng, I Tirosh, Isaac M. Chiu, J Beale, J von Moltke, JA Hedrick, Jackson Nyman, JC Nussbaum, John J. Trombetta, JT Gaublomme, K Branchfield, K Kurakula, K Moro, K Shekhar, KJ Audrit, L Shan, LA Monticelli, LA Monticelli, M Gury-BenAri, M Moriyama, M Salimi, M Schuliga, M Singer, Matan Hofree, Michael S. Cuoco, ML Robinette, Monika S. Kowalczyk, MR Howitt, MS Kowalczyk, N Habib, NL Bray, NM Heshmat, Orit Rozenblatt-Rosen, Pankaj Baral, Patrick R. Burkett, PG Szekeres, R Satija, Raja-Elie E. Abdulnour, S Picelli, S Talbot, Samantha J. Riesenfeld, T Katsunuma, T Polte, T Sekigawa, Tanel Mahlakõiv, Timothy L. Tickle, TY Halim, Vijay K. Kuchroo, X Gu, Y Huang, YJ Chang   +71 more
core   +1 more source

Alarmin Cytokines as Central Regulators of Cutaneous Immunity

Frontiers in Immunology, 2022
Skin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that provide the first line of defense against microbial pathogens and environmental insults ...
Tatsuya Hasegawa, Tomonori Oka, Shadmehr Demehri   +2 more
doaj   +1 more source

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation [PDF]

, 2016
Additional file 2: Table S2. Primary and secondary antibodies used during western blot analysis of lung homogenate samples. All primary antibodies were diluted in TBS-T with 5 % BSA, while the secondary antibody was diluted in TBS-T with 5 ...
Akbarshahi, Hamid,, Brandelius, Angelica,, Lund University., Mahmutovic Persson, Irma,, Menzel, Mandy,, Uller, Lena,   +5 more
core   +4 more sources

Replicating viral vector platform exploits alarmin signals for potent CD8⁺ T cell-mediated tumour immunotherapy. [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL ^eff ) responses. Conversely, the induction of protective tumour-specific CTL ^eff and their recruitment into the
A Hyvarinen, A Plyusnin, A Wortmann, AM Henao-Restrepo, C Baumann, C Butts, CA Klebanoff, CB Stephensen, D Peng, D Valmori, D Zamarin, DA Enria, DK Reichenbach, DL Popkin, E Scandella, ER Chare, F Duan, F Pages, F Spertini, GP Dunn, HE Webb, J Delaloye, J Liu, J Zhu, JA Joyce, JF Vansteenkiste, JY Liu, K Oboki, KM Quinn, L Flatz, L Flatz, L Flatz, L Zhang, LC Anton, M Lewandoski, M Peine, M Perez, M Suter, M Vanneman, MD Stenglein, MF Callan, MF Kotturi, MJ Townsend, N Fasnacht, O Kew, P Grob, P Sharma, PC Doherty, PC Tumeh, PW Kantoff, R Schirmbeck, R Sommerstein, RH Andtbacka, RM Zinkernagel, RM Zinkernagel, S Darbre, S Spranger, SA Fuertes Marraco, SA Rosenberg, SF Emonet, SG Hansen, SN Mueller, T Querec, TF Gajewski, TN Schumacher, WV Bonilla, WV Bonilla, X de Lamballerie, Y Iwai, Z Waibler   +69 more
core   +2 more sources

Extracellular Nucleophosmin Is Increased in Psoriasis and Correlates With the Determinants of Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting ...
Marco D'Agostino, Sara Beji, Sara Sileno, Daniela Lulli, Laura Mercurio, Stefania Madonna, Corrado Cirielli, Sabatino Pallotta, Cristina Albanesi, Maurizio C. Capogrossi, Maurizio C. Capogrossi, Daniele Avitabile, Guido Melillo, Alessandra Magenta   +13 more
doaj   +1 more source

Cleavage-Resistant CYLD Protects Against Autoimmune Hepatitis. [PDF]

Adv Sci (Weinh)
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Liu H, Su C, Liu J, Xing M, Wu X, Wang L, Zhao X, Zhang H, Xie Y, Wang Y, Li H, Li Y, Li M, Zhang H.   +13 more
europepmc   +2 more sources

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Millar, N.L., Murrell, G.A.C.
core   +3 more sources

Alarmins, inflammasomes and immunity

Biomedical Journal, 2012
The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs).
Najwane Saïd-Sadier, David M Ojcius
openaire   +3 more sources

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

Cell Reports, 2017
From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and infection.
Simona Saluzzo, Anna-Dorothea Gorki, Batika M.J. Rana, Rui Martins, Seth Scanlon, Philipp Starkl, Karin Lakovits, Anastasiya Hladik, Ana Korosec, Omar Sharif, Joanna M. Warszawska, Helen Jolin, Ildiko Mesteri, Andrew N.J. McKenzie, Sylvia Knapp   +14 more
doaj   +1 more source

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline [PDF]

, 2016
Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment.
Chan, Ivy C. W., Cheung, Tom H., Fu, Amy K. Y., Fu, Wing-Yu, Hung, Kwok-Wang, Ip, Nancy Y., Liew, Foo Y., Mak, Deejay S. Y., Yuen, Michael Y. F., Zhang, Baorong, Zhou, Xiaopu   +10 more
core   +1 more source