Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation [PDF]
Frontiers in Immunology, 2015 Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
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Promoting immune defensive responses of epithelial cells in airway disease [PDF]
Frontiers in AllergyThe airway epithelium serves as both a physical barrier and as an active contributor in maintaining immune defense. Upon exposure to external insults such as injury and infection, the epithelium releases alarmins including interleukin-25 (IL-25), IL-33 ...
Michael J. Parnham +2 more
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Enhanced Alarmin Secretion Exacerbates Neutrophil Extracellular Trap (NET) Formation in Active Psoriasis: Implication of IL-33 and TSLP in Driving NET Formation, Inflammation and Oxidative Stress in Psoriasis [PDF]
AntioxidantsPsoriasis is a common inflammatory skin disease with chronic manifestation in which the role of neutrophil extracellular traps (NETs) and alarmins are increasingly recognized as contributors to systemic and cutaneous inflammation.
Vanshika Ojha +2 more
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Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases
Cells, 2022 Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Ken Fukuda +6 more
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Alarmins/stressorins and immune dysregulation in intractable skin disorders
Allergology International, 2021 Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults ...
Kiyofumi Yamanishi, Yasutomo Imai
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Biomedicines, 2021 Alarmins are innate cytokines, including thymic stromal lymphopoietin (TSLP), interleukin-33 (IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and exert a prominent role in asthma pathobiology.
Corrado Pelaia +7 more
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Gastric alarmin release: A warning signal in the development of gastric mucosal diseases
Frontiers in Immunology, 2022 Alarmins exist outside cells and are early warning signals to the immune system; as such, alarmin receptors are widely distributed on various immune cells.
Enqin Wu +7 more
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The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury
Frontiers in Medicine, 2020 Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain immune ...
Vikram Sabapathy +3 more
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Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
Cells, 2020 Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases.
Nina D. Anfinogenova +3 more
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Medicina, 2022 Schizophrenia, consisting of a group of severe psychiatric disorders with a complex etiology, is a leading cause of disability globally. Due to the lack of objective indicators, accurate diagnosis and selection of effective treatments for schizophrenia ...
Huan Ma, Ning Cheng, Caiyi Zhang
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