Results 11 to 20 of about 13,578 (213)

Alarmins, COVID-19 and comorbidities [PDF]

Annals of Medicine, 2021
The coronavirus SARS-CoV-2, the aetiological agent of COVID-19 disease, is representing a worldwide threat for the medical community and the society at large so that it is being defined as “the twenty-first-century disease”.
Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi   +4 more
doaj   +4 more sources

Nuclear Alarmin Cytokines in Inflammation [PDF]

Journal of Immunology Research, 2020
Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Lili Jiang, Yijia Shao, Yao Tian, Changsheng Ouyang, Xiaohua Wang   +4 more
doaj   +4 more sources

Alarmins and immunity [PDF]

Immunological Reviews, 2017
SummaryMore than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host ...
De Yang, Zhen Han, Joost J. Oppenheim
openaire   +2 more sources

Alarmins and antimicrobial immunity [PDF]

Medical Mycology, 2009
Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of ...
D, Yang, J J, Oppenheim
openaire   +2 more sources

Alarmins and Antitumor Immunity [PDF]

Clinical Therapeutics, 2016
Alarmins are constitutively present endogenous molecules that essentially act as early warning signals for the immune system. We provide a brief overview of major alarmins and highlight their roles in tumor immunity.We searched PubMed up to January 10, 2016, using alarmins and/or damage-associated molecular patterns (DAMPs), as key words.
Yingjie, Nie, De, Yang, Joost J, Oppenheim   +2 more
openaire   +2 more sources

Sounding the alarmins—The role of alarmin cytokines in asthma

Allergy, 2022
AbstractThe alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2
Gail M. Gauvreau, Celine Bergeron, Louis‐Philippe Boulet, Donald W. Cockcroft, Andréanne Côté, Beth E. Davis, Richard Leigh, Irvin Myers, Paul M. O'Byrne, Roma Sehmi   +9 more
openaire   +2 more sources

Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis

Acta Medica, 2022
Background. Psoriasis is a chronic systemic inflammatory disease with (extra-)cutaneous manifestations. Inflammation is associated with cellular stress and tissue damage which lead to the release of alarmins (signals of danger).
Drahomíra Holmannová, Barbora Císařová, Pavel Borský, Zdeněk Fiala, Ctirad Andrýs, Květoslava Hamaková, Tereza Švadláková, Jan Krejsek, Vladimír Palička, Lenka Kotingová, Lenka Borská   +10 more
doaj   +1 more source

Cleavage-Resistant CYLD Protects Against Autoimmune Hepatitis. [PDF]

Adv Sci (Weinh)
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Liu H, Su C, Liu J, Xing M, Wu X, Wang L, Zhao X, Zhang H, Xie Y, Wang Y, Li H, Li Y, Li M, Zhang H.   +13 more
europepmc   +2 more sources

Alarmins: Feel the Stress [PDF]

The Journal of Immunology, 2017
Abstract Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the “danger hypothesis,” it was recently shown that alarmins can also directly ...
Rider, P., Voronov, E., Dinarello, C.A., Dinarello, C.A., Apte, R.N., Cohen, I.   +5 more
openaire   +2 more sources

Alarmins in Osteoporosis, RAGE, IL-1, and IL-33 Pathways: A Literature Review

Medicina, 2020
Alarmins are endogenous mediators released by cells following insults or cell death to alert the host’s innate immune system of a situation of danger or harm.
Massimo De Martinis, Lia Ginaldi, Maria Maddalena Sirufo, Giovanni Pioggia, Gioacchino Calapai, Sebastiano Gangemi, Carmen Mannucci   +6 more
doaj   +1 more source