One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
Alarmins in frozen shoulder: a molecular association between inflammation and pain [PDF]
, 2017 Background: The pathophysiological mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear.
Akbar, Moeed +10 more
core +1 more source
Alarmin‐induced cell migration [PDF]
European Journal of Immunology, 2013 Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the induction of innate and adaptive immune responses. For our immune system to function appropriately, it relies on navigating various leukocytes to distinct places at the right time.
De, Yang +4 more
openaire +2 more sources
Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]
, 2018 The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda +7 more
core +1 more source
Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases
Frontiers in Immunology, 2019 Autoimmune and auto-inflammatory diseases in children are causing chronic inflammation, organ damage, and pain. Although several options for treatment are nowadays available a significant number of patients does not respond sufficiently to current ...
Dirk Holzinger +2 more
doaj +1 more source
Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model [PDF]
, 2016 A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis.
Ayati, Bruce P. +4 more
core +3 more sources
S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation
Frontiers in Immunology, 2020 The restricted capacity of newborn infants to mount inflammatory responses toward microbial challenges has traditionally been linked to the high risk of septic diseases during the neonatal period.
Dorothee Viemann +2 more
doaj +1 more source
The GAR/RGG motif defines a family of nuclear alarmins
Cell Death and Disease, 2021 The nucleus is the target of autoantibodies in many diseases, which suggests intrinsic nuclear adjuvants that confer its high autoimmunogenicity. Nucleolin (NCL) is one abundant nucleolar autoantigen in systemic lupus erythematosus (SLE) patients and, in
Shan Wu +4 more
doaj +1 more source
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
core +1 more source
Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
Mediators of Inflammation, 2020 Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic ...
Pavel Borsky +10 more
doaj +1 more source