Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?
Biomolecules, 2018 Autism spectrum disorders (ASDs) represent a disabling condition in early childhood. A number of risk factors were proposed in order to explain their pathogenesis.
Eleonora Di Salvo +4 more
doaj +1 more source
Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion [PDF]
, 2009 IntroductionHigh mobility group box nuclear protein 1 (HMGB1) is a DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like-receptor ...
Mitchell J Cohen +8 more
core +2 more sources
The perioperative immune response [PDF]
, 2015 PURPOSE OF REVIEW A host of immune modulators are now available in clinical practice. The perioperative period is characterized by profound alterations in host immunity, which can result in poor outcomes, which include infection, cancer recurrence and
Akira +50 more
core +1 more source
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets
BiomedicinesAsthma is a chronic respiratory condition predominantly driven by a type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells and ...
Ravneet K. Hansi +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Diabetes mellitus is linked with metabolic stress that induces cellular damage and can provoke renal inflammation and fibrotic responses that eventually lead to chronic kidney disease. Because the inflammasome, interleukin 1 (IL-1), IL-1α/IL-β, and IL-1R
Talal Salti +8 more
doaj +1 more source
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling
Clinical and Translational Medicine, 2023 Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown.
Yuyang Sun +10 more
doaj +1 more source
Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin
Cells, 2022 Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts ...
Luc Rochette +5 more
doaj +1 more source
The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis
Current Issues in Molecular BiologyAlarmins are immune-activating factors released after cellular injury or death. By secreting alarmins, cells can interact with immune cells and induce a variety of inflammatory responses.
Kajetan Kiełbowski +4 more
doaj +1 more source
Novel Biological Therapies for Severe Asthma Endotypes
Biomedicines, 2022 Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia +8 more
doaj +1 more source
The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [PDF]
, 2014 BACKGROUND: The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic ...
Bobek, Dubravka +4 more
core +1 more source