Results 51 to 60 of about 13,578 (213)
Alarmins, inflammasomes and immunity
Biomedical Journal, 2012 The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs).
Najwane Saïd-Sadier, David M Ojcius
openaire +3 more sources
Frontiers in Immunology, 2021 Nowadays, in the study of rheumatoid arthritis (RA), more and more interest is directed towards an earlier effective therapeutic intervention and the determination of companion markers for predicting response to therapy with the goal to prevent ...
Federica Ciregia +10 more
doaj +1 more source
Heat shock proteins in tendinopathy: novel molecular regulators [PDF]
, 2012 Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Millar, N.L., Murrell, G.A.C.
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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [PDF]
, 2018 Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance.
Duregotti, E +10 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley +1 more source
Salivary Levels of S100A8, S100A9 and S100A8/9 in Periodontal Health and Disease: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Damage Associated Molecular Patterns (DAMPs) can initiate and amplify immune responses and can play an important role in the sustenance and progression of periodontal diseases.
Annie Kitty George +4 more
doaj +1 more source
Stroke and the immune system: A review of the new strategies [PDF]
Folia Medica, 2020 The immunology of stroke can be approached in several ways. By viewing stroke from an immunological standpoint, we are trying to achieve new insights in its pathogenesis and reach new therapeutic options.
Valentin Todorov, Maria Dimitrova
doaj +3 more sources
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease [PDF]
, 2015 MicroRNA (miRNA) has the potential for cross-regulation and functional integration of discrete biological processes during complex physiological events.
Akbar, Moeed +9 more
core +1 more source
Alarmins link neutrophils and dendritic cells [PDF]
Trends in Immunology, 2009 Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and adaptive immunity. Although the contribution of neutrophils to innate immune defense is mediated predominantly by phagocytosis and killing of microorganisms, neutrophils also participate in the ...
De, Yang +3 more
openaire +2 more sources