Results 61 to 70 of about 13,578 (213)

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Frontiers in Immunology, 2021
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC−/−) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic ...
Mariska T. Meijer, Mariska T. Meijer, Alex F. de Vos, Alex F. de Vos, Brendon P. Scicluna, Brendon P. Scicluna, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Gertraud Orend, Fabrice Uhel, Fabrice Uhel, Tom van der Poll, Tom van der Poll, Tom van der Poll   +14 more
doaj   +1 more source

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

S100A8 & S100A9: Alarmin mediated inflammation in tendinopathy [PDF]

Scientific Reports, 2019
AbstractAlarmins S100A8 and S100A9 are endogenous molecules released in response to environmental triggers and cellular damage. They are constitutively expressed in immune cells such as monocytes and neutrophils and their expression is upregulated under inflammatory conditions.
Crowe, Lindsay A.N., McLean, Michael, Kitson, Susan M., Garcia Melchor, Emma, Patommel, Katharina, Cao, Hai Man, Reilly, James H., Leach, William J., Rooney, Brain P., Spencer, Simon J., Mullen, Michael, Chambers, Max, Murrell, George A.C., McInnes, Iain B., Akbar, Moeed, Millar, Neal L.   +15 more
openaire   +3 more sources

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention

European Journal of Medical Research
Alarmins are a class of molecules released when affected cells damaged or undergo apoptosis. They contain various chemotactic and immunomodulatory proteins or peptides.
Qiqi Zhang, Dandan Yang, Xingxing Han, Yu Ren, Yongqi Fan, Chao Zhang, Lei Sun, Tingting Ye, Qiushuang Wang, Youhao Ban, Yunxia Cao, Huijuan Zou, Zhiguo Zhang   +12 more
doaj   +1 more source

PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy

Frontiers in Physiology, 2020
Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it
Andrea Farini, Chiara Villa, Dario Di Silvestre, Pamela Bella, Luana Tripodi, Rossana Rossi, Clementina Sitzia, Stefano Gatti, Pierluigi Mauri, Yvan Torrente   +9 more
doaj   +1 more source

A Measure of Control for Secondary Cytokine-Induced Injury of Articular Cartilage: A Computational Study [PDF]

, 2013
In previous works, the author and collaborators establish a mathematical model for injury response in articular cartilage. In this paper we use mathematical software and computational techniques, applied to an existing model to explore in more detail how
Graham, Jason M
core  

Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma [PDF]

, 2010
Introduction: High mobility group box 1 (HMGB1) is a key mediator of inflammation that is actively secreted by macrophages and/or passively released from damaged cells.
Valeria Manganelli, Michele Signore, Ilaria Pacini, Roberta Misasi, Guglielmo Tellan, Tina Garofalo, Emanuela Lococo, Piero Chirletti, Maurizio Sorice, Giovanna Delogu   +9 more
core   +1 more source

Alarmins and Related Molecules in Elective Surgery

Folia Biologica, 2023
Surgery is associated with alterations of alarmins’ and related molecules’ levels. The aim of this study was to investigate which biomarkers are most involved in surgery. The studied group consisted of 58 patients with inguinal or umbilical hernia or cholecystolithiasis and 21 healthy controls for compa­rison.
Sabina, Strohalmová, Kateřina, Levová, Aleš Antonín, Kuběna, David, Hoskovec, Zdeněk, Krška, Tomáš, Zima, Marta, Kalousová   +6 more
openaire   +2 more sources