Results 81 to 90 of about 13,578 (213)

Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

Microbiology Spectrum, 2021
Tenascin C (TNC) is an extracellular matrix protein with immunomodulatory properties that plays a major role during tissue injury and repair. TNC levels are increased in patients with pneumonia and pneumosepsis, and they are associated with worse ...
Mariska T. Meijer, Alex F. de Vos, Hessel Peters Sengers, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Fabrice Uhel, Gertraud Orend, Tom van der Poll   +8 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives

Biomedicines
Background: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment.
Angela Rizzi, Federica Li Pomi, Riccardo Inchingolo, Marinella Viola, Francesco Borgia, Sebastiano Gangemi   +5 more
doaj   +1 more source

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation [PDF]

, 2018
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular
A Dixit, A Jäger, A Tanay, A Wagner, AK Björklund, Antonia Wallrapp, Aviv Regev, BD Modena, Brian J. Haas, Bruce D. Levy, C Soneson, CE Prendergast, Christoph S. N. Klose, Christopher Rodman, D Cheng, Daneyal Farouq, Danielle Dionne, David Artis, DF Gudbjartsson, DR Neill, F Gerbe, GX Zheng, I Tirosh, Isaac M. Chiu, J Beale, J von Moltke, JA Hedrick, Jackson Nyman, JC Nussbaum, John J. Trombetta, JT Gaublomme, K Branchfield, K Kurakula, K Moro, K Shekhar, KJ Audrit, L Shan, LA Monticelli, LA Monticelli, M Gury-BenAri, M Moriyama, M Salimi, M Schuliga, M Singer, Matan Hofree, Michael S. Cuoco, ML Robinette, Monika S. Kowalczyk, MR Howitt, MS Kowalczyk, N Habib, NL Bray, NM Heshmat, Orit Rozenblatt-Rosen, Pankaj Baral, Patrick R. Burkett, PG Szekeres, R Satija, Raja-Elie E. Abdulnour, S Picelli, S Talbot, Samantha J. Riesenfeld, T Katsunuma, T Polte, T Sekigawa, Tanel Mahlakõiv, Timothy L. Tickle, TY Halim, Vijay K. Kuchroo, X Gu, Y Huang, YJ Chang   +71 more
core   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways [PDF]

, 2013
Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC) permeability.
Adibnia, Yasaman, Hauser, Carl J, Itagaki, Kiyoshi, Li, Haipeng, Otterbein, Leo E., Sun, Shiqin, Sursal, Tolga, Zhao, Cong, Zheng, Yi   +8 more
core   +2 more sources

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries [PDF]

, 2019
Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-hospital outcomes for trauma survivors; accordingly, we examined the complex association between clinical outcomes inflammatory responses in this setting using in ...
Abboud, Andrew, Almahmoud, Khalid, Billiar, Timothy R., Gaski, Greg E., McKinley, Todd O., Namas, Rami A., Peitzman, Andrew B., Sperry, Jason, Truitt, Michael S., Vodovotz, Yoram, Zamora, Ruben   +10 more
core   +3 more sources

Prothymosin Alpha: An Alarmin and More...

Current Medicinal Chemistry, 2017
Prothymosin alpha (proTα) is a ubiquitous polypeptide first isolated by Haritos in 1984, whose role still remains partly elusive. We know that proTα acts both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similarly to molecules termed as "alarmins". Our
Samara, P., Karachaliou, C.-E., Ioannou, K., Papaioannou, N.E., Voutsas, I.F., Zikos, C., Pirmettis, I., Papadopoulos, M., Kalbacher, H., Livaniou, E., Tsitsilonis, O.E., Voelter, W.   +11 more
openaire   +3 more sources