New therapeutic approaches to the alphaherpesvirus infections [PDF]
The character of diseases caused by alphaherpesviruses has changed over the last decade. The severity of disease and the frequency of acyclovir resistance has increased with the increase in the number of immunocompromised patients. Compounding the trend towards more virulent herpes disease is the current emphasis towards outpatient management of many ...
K A, Cassady, R J, Whitley
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Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses
Herpes simplex viruses (HSVs) are neurotropic viruses with broad host range whose infections cause considerable health problems in both animals and humans.
Sabina Andreu +3 more
doaj +1 more source
In Vivo Egress of an Alphaherpesvirus from Axons [PDF]
ABSTRACT Many alphaherpesviruses establish a latent infection in the peripheral nervous systems of their hosts. This life cycle requires the virus to move long distances in axons toward the neuron's cell body during infection and away from the cell body during reactivation.
Mark J, Tomishima, Lynn W, Enquist
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Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses
Alphaherpesviruses cause various diseases and establish life-long latent infections in humans and animals. These viruses encode multiple viral proteins and miRNAs to evade the host immune response, including both innate and adaptive immunity ...
Naoto Koyanagi, Yasushi Kawaguchi
doaj +1 more source
Isolation and characterization of a chimpanzee alphaherpesvirus
Although both beta- and gammaherpesviruses indigenous to great-ape species have been isolated, to date all alphaherpesviruses isolated from apes have proven to be human viruses [herpes simplex virus types 1 (HSV1) and 2 (HSV2) or varicella-zoster virus].
Emily, Luebcke +4 more
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The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection
Many viruses require the maintenance of lysosomal cholesterol homeostasis for a successful infection; however, the role of lysosomal cholesterol homeostasis in the alphaherpesvirus life cycle is not clear.
Byeongwoon Song
doaj +1 more source
A Common Neuronal Response to Alphaherpesvirus Infection [PDF]
Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus-host interaction in these cells.
Moriah L, Szpara +2 more
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Infectious Disease Outbreak Associated With Supplementary Feeding of Semi-domesticated Reindeer
Supplementary winter feeding of semi-domesticated reindeer (Rangifer tarandus tarandus) has become more common in Sweden and Norway due to reindeer pasture fragmentation and climatic conditions.
Morten Tryland +6 more
doaj +1 more source
Genetic and Antigenic Diversity of <i>Bubaline alphaherpesvirus 1</i>. [PDF]
Bubaline alphaherpesvirus 1 (BuHV-1) is a virus that belongs to the Varicellovirus genus within the Alphaherpesvirinae subfamily. While BuHV-1 infections in water buffaloes (Bubalus bubalis) are often subclinical, clinical manifestations have been reported.
Tau RL +8 more
europepmc +3 more sources
Alphaherpesvirus Major Tegument Protein VP22: Its Precise Function in the Viral Life Cycle
Alphaherpesviruses are zoonotic pathogens that can cause a variety of diseases in humans and animals and severely damage health. Alphaherpesvirus infection is a slow and orderly process that can lie dormant for the lifetime of the host but may be ...
Liping Wu +62 more
doaj +1 more source

