Results 81 to 90 of about 47,553 (202)

A New Approach to Assessing HSV-1 Recombination during Intercellular Spread

Viruses, 2018
The neuroinvasive Herpes simplex virus type 1 (HSV-1) utilizes intergenomic recombination in order to diversify viral populations. Research efforts to assess HSV-1 recombination are often complicated by the use of attenuating mutations, which ...
Gabrielle A. Law, Alix E. Herr, James P. Cwick, Matthew P. Taylor   +3 more
doaj   +1 more source

HSV‐1 US3: A Master Mimic Hijacking Host Kinase Networks for Viral Dominance

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Herpes simplex virus type 1 (HSV‐1) encodes the serine/threonine kinase US3, a central regulator of host–virus interactions that promotes viral replication, latency, and reactivation. Despite limited sequence homology to cellular kinases such as Akt or PKA, US3 phosphorylates diverse substrates to manipulate multiple pathways.
Imran Hossain, Christella J. Nelson, Ojasvi Dutta, Harikrishnan Mohan, Mehedi Hasan, Konstantin G. Kousoulas   +5 more
wiley   +1 more source

Assembly and Egress of an Alphaherpesvirus Clockwork [PDF]

, 2017
All viruses produce infectious particles that possess some degree of stability in the extracellular environment yet disassemble upon cell contact and entry. For the alphaherpesviruses, which include many neuroinvasive viruses of mammals, these metastable virions consist of an icosahedral capsid surrounded by a protein matrix (referred to as the ...
openaire   +2 more sources

Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia [PDF]

Journal of NeuroVirology, 2016
Analysis of the frequency and PCR-quantifiable abundance of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in multiple biological replicates of cells from dissociated randomly distributed human trigeminal ganglia (TG) of four subjects revealed an increase in both parameters and in both viruses during 5 days of culture, with no
Randall J, Cohrs, Hussain, Badani, Nathan, Bos, Charles, Scianna, Ian, Hoskins, Nicholas L, Baird, Don, Gilden   +6 more
openaire   +2 more sources

Molecular characterization of equine herpes viruses type 1 and 4 among Arabian horse populations in Egypt during the period between 2021-2022

Open Veterinary Journal
Background: Equine herpesvirus type 1 (EHV-1) is a major cause of abortion and respiratory disease. Equine herpesvirus type 4 (EHV-4), on the other hand, is exclusively associated with respiratory disease in horse populations worldwide, particularly in ...
Ahmed A.H. Ali, Fatma Abdallah, Omayma A. Shemies, Gamilat A.H. Kotb, Maged R. Nafea   +4 more
doaj   +1 more source

Decoding the Architecture of the Varicella-Zoster Virus Transcriptome

mBio, 2020
Varicella-zoster virus (VZV), a double-stranded DNA virus, causes varicella, establishes lifelong latency in ganglionic neurons, and reactivates later in life to cause herpes zoster, commonly associated with chronic pain. The VZV genome is densely packed
Shirley E. Braspenning, Tomohiko Sadaoka, Judith Breuer, Georges M. G. M. Verjans, Werner J. D. Ouwendijk, Daniel P. Depledge   +5 more
doaj   +1 more source

Histopathological and genetic characterisation of Marek's disease in Sebright chickens from Brazil

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract Marek's disease is a lymphoproliferative condition caused by Gallid alphaherpesvirus 2 (Marek's disease virus), affecting primarily birds of the order Galliformes. This study reports a case of Marek's disease in Sebright chickens in Rio de Janeiro, Brazil.
Thomas Salles Dias, Catia Dejuste de Paula, Andrea Soffiatti Grael, Carlos Henrique Campelllo Costa, Aniesse Silva Aguiar, Dayse Lima da Costa Abreu   +5 more
wiley   +1 more source

Tethered release of the pseudorabies virus deubiquitinase from the capsid promotes enzymatic activity

Journal of Virology
Herpesviruses carry an assortment of proteins in the interstitial space between the capsid and membrane envelope, collectively referred to as the tegument.
Sarah E. Antinone, John S. Miller, Nicholas J. Huffmaster, Gary E. Pickard, Gregory A. Smith   +4 more
doaj   +1 more source

Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy. [PDF]

, 2008
Gammaherpesviruses, including the human pathogens Epstein-Barr virus and Kaposi\u27s sarcoma-associated herpesvirus, are causative agents of lymphomas and other malignancies.
Atanasov, Ivo, Bortz, Eric, Dai, Wei, Jia, Qingmei, Li, Xudong, Liu, Jun, Shah, Sanket, Sun, Ren, Taylor, Kenneth A, Zhou, Z Hong   +9 more
core   +1 more source

Alphaherpesvirus in Pets and Livestock

Microorganisms
Herpesviruses are a group of DNA viruses capable of infecting multiple mammalian species, including humans. This review primarily summarizes four common alphaherpesviruses found in pets and livestock (feline, swine, canine, and bovine) in aspects such as epidemiology, immune evasion, and latency and reactivation.
Shu-Hui Duan, Ze-Min Li, Xue-Jie Yu, Dan Li   +3 more
openaire   +2 more sources