Antiviral Strategies against Arthritogenic Alphaviruses [PDF]
Microorganisms, 2020 Alphaviruses are members of the Togaviridae family that are mainly transmitted by arthropods such as mosquitoes. In the last decades, several alphaviruses have re-emerged, causing outbreaks worldwide. One example is the re-emergence of chikungunya virus (
Rana Abdelnabi, Leen Delang
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The alphaviruses: gene expression, replication, and evolution [PDF]
Microbiological reviews, 1994 The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
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YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses [PDF]
Journal of VirologyChikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li +5 more
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VLDLR and ApoER2 are receptors for multiple alphaviruses [PDF]
Nature, 2021 Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect vectors separated by hundreds of millions of years of evolutionary history.
Lars E. Clark +18 more
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Innate immune evasion by alphaviruses
Frontiers in Immunology, 2022 Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection.
Yihan Liu +7 more
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Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
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A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses [PDF]
Viruses, 2019 Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of the Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash and incapacitating poly-arthralgia ...
Yessica Y. Llamas-González +4 more
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Role of macrophages in the onset, maintenance, or control of arthritis caused by alphaviruses [PDF]
Experimental biology and medicine, 2023 Arthritogenic alphaviruses are mosquito-borne viruses that cause a debilitating rheumatic disease characterized by fever, headache, rash, myalgia, and polyarthralgia with the potential to evolve into a severe and very prolonged illness.
Matheus O. Atella +2 more
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Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures [PDF]
VirusesChikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M. Lantz, Victoria K. Baxter
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Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses [PDF]
Virus ResearchAlphaviruses in the family Togaviridae include zoonotic arthropod-borne viruses, including Sindbis virus (SINV), chikungunya virus, as well as insect-specific viruses such as Eilat virus (EILV).
Chadwic De’Sean Mears +10 more
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