Results 11 to 20 of about 15,705 (275)

Alphaviruses in Immunotherapy and Anticancer Therapy [PDF]

Biomedicines, 2022
Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundström
semanticscholar   +5 more sources

Alphaviruses in Cancer Therapy

Frontiers in Molecular Biosciences, 2022
Alphaviruses have been engineered as expression vectors for different strategies of cancer therapy including immunotherapy and cancer vaccine development.
K. Lundstrom
semanticscholar   +4 more sources

Alphaviruses Detected in Mosquitoes in the North-Eastern Regions of South Africa, 2014 to 2018

Viruses, 2023
The prevalence and distribution of African alphaviruses such as chikungunya have increased in recent years. Therefore, a better understanding of the local distribution of alphaviruses in vectors across the African continent is important.
Milehna M. Guarido, Isabel Fourie, Kgothatso Meno, Adriano Mendes, Megan A. Riddin, Caitlin MacIntyre, Sontaga Manyana, Todd Johnson, Maarten Schrama, Erin E. Gorsich, Basil D. Brooke, Antonio Paulo G. Almeida, Marietjie Venter   +12 more
doaj   +2 more sources

Evidence of Differences in Cellular Regulation of Wolbachia-Mediated Viral Inhibition between Alphaviruses and Flaviviruses [PDF]

Viruses
The intracellular bacterium Wolbachia is increasingly being utilised in control programs to limit the spread of arboviruses by Aedes mosquitoes. Achieving a better understanding of how Wolbachia strains can reduce viral replication/spread could be ...
Stephanie M. Rainey, Daniella A. Lefteri, Christie Darby, Alain Kohl, Andres Merits, Steven P. Sinkins   +5 more
doaj   +2 more sources

The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells

Frontiers in Microbiology, 2021
Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the Togaviridae family.
Lien De Caluwé, Sandra Coppens, Katleen Vereecken, Simon Daled, Maarten Dhaenens, Xaveer Van Ostade, Dieter Deforce, Kevin K. Ariën, Koen Bartholomeeusen   +8 more
openalex   +2 more sources

Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents [PDF]

Viruses
Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world.
Kenneth Lundstrom
doaj   +2 more sources

Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity [PDF]

Frontiers in Public Health
Arboviruses represent a global public health challenge. The lack of diagnostic protocols and the presence of asymptomatic infections complicate confirmatory diagnostics.
Andrea Valles-Morera, Tatiana Murillo, Jose Lizano-Bolaños, Sergio Gutierrez-Roche, Margarita Alvarado, Jonathan Alfaro-Alvarado, Gerardo Andrés Calvo-Salas, Grace Prado-Hidalgo, Johis Ortega, Eugenia Corrales-Aguilar   +9 more
doaj   +2 more sources

Activation of the PI3K-AKT Pathway by Old World Alphaviruses

Cells, 2020
Alphaviruses can infect a broad range of vertebrate hosts, including birds, horses, primates, and humans, in which infection can lead to rash, fever, encephalitis, and arthralgia or arthritis.
Eline Van Huizen, Gerald M. McInerney
doaj   +2 more sources

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ^®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow   +16 more
doaj   +2 more sources

Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

Microorganisms, 2019
Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it
Laura I. Levi, Marco Vignuzzi
doaj   +2 more sources