Results 11 to 20 of about 15,327 (237)
Innate immune evasion by alphaviruses
Frontiers in Immunology, 2022 Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection.
Yihan Liu +7 more
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YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses [PDF]
Journal of VirologyChikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li +5 more
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Antiviral Strategies against Arthritogenic Alphaviruses [PDF]
Microorganisms, 2020 Alphaviruses are members of the Togaviridae family that are mainly transmitted by arthropods such as mosquitoes. In the last decades, several alphaviruses have re-emerged, causing outbreaks worldwide. One example is the re-emergence of chikungunya virus (
Rana Abdelnabi, Leen Delang
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Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
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Alphaviruses Detected in Mosquitoes in the North-Eastern Regions of South Africa, 2014 to 2018
Viruses, 2023 The prevalence and distribution of African alphaviruses such as chikungunya have increased in recent years. Therefore, a better understanding of the local distribution of alphaviruses in vectors across the African continent is important.
Milehna M. Guarido +12 more
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The alphaviruses: gene expression, replication, and evolution [PDF]
Microbiological reviews, 1994 The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
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Neuropathogenesis of Old World Alphaviruses: Considerations for the Development of Medical Countermeasures [PDF]
VirusesChikungunya virus (CHIKV) and other alphaviruses that primarily induce arthritogenic disease in humans, known as “Old World” alphaviruses, present an emerging public health concern as geographic ranges of mosquito vectors expand due to climate change ...
Alyssa M. Lantz, Victoria K. Baxter
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Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses [PDF]
Virus ResearchAlphaviruses in the family Togaviridae include zoonotic arthropod-borne viruses, including Sindbis virus (SINV), chikungunya virus, as well as insect-specific viruses such as Eilat virus (EILV).
Chadwic De’Sean Mears +10 more
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Alphaviruses in Cancer Therapy
Frontiers in Molecular Biosciences, 2022 Alphaviruses have been engineered as expression vectors for different strategies of cancer therapy including immunotherapy and cancer vaccine development.
K. Lundstrom
semanticscholar +4 more sources
Activation of the PI3K-AKT Pathway by Old World Alphaviruses
Cells, 2020 Alphaviruses can infect a broad range of vertebrate hosts, including birds, horses, primates, and humans, in which infection can lead to rash, fever, encephalitis, and arthralgia or arthritis.
Eline Van Huizen, Gerald M. McInerney
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