Results 21 to 30 of about 15,705 (275)

Low capacity for molecular detection of Alphaviruses other than Chikungunya virus in 23 European laboratories, March 2022. [PDF]

PLoS ONE
Alphaviruses comprise over 30 identified species spread worldwide and carry a large global health burden. With vector expansion occurring in and around Europe, it is anticipated this burden will increase.
Laura Pezzi, Ramona Moegling, Cécile Baronti, Kamelia R Stanoeva, Lance D Presser, Pauline Jourdan, Nazli Ayhan, Willem M R van den Akker, Stephan Zientara, Céline M Gossner, Rémi N Charrel, Chantal B E M Reusken, EVD-LabNet   +12 more
doaj   +2 more sources

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry. [PDF]

PLoS Pathogens
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan   +9 more
doaj   +2 more sources

Eilat virus isolated from Culex univittatus mosquitoes from the Namibian Zambezi Region influences in vitro superinfection with alpha- and flaviviruses in a virus-species-dependent manner. [PDF]

PLoS ONE
The genus Alphavirus harbors arboviruses of great concern, such as the Chikungunya virus and the equine encephalitis viruses. Transmission of pathogenic alphaviruses by mosquitoes could be influenced by insect-specific alphaviruses such as Eilat virus ...
Heiko D Guggemos, Anne Kopp, Katrin Voigt, Matthias Fendt, Selina L Graff, John K E Mfune, Christian Borgemeister, Sandra Junglen   +7 more
doaj   +2 more sources

The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses

Cell Reports
Sathvik Palakurty, Saravanan Raju, Alan Sariol, Zhenlu Chong, Ngan Wagoner, Hongming Ma, Ofer Zimmerman, Lucas J. Adams, Camille Carmona, Zhuoming Liu, Daved H. Fremont, Sean P. J. Whelan, William B. Klimstra, Michael S. Diamond   +13 more
openalex   +2 more sources

Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site [PDF]

Cell Host and Microbe, 2020
Laura A. Powell, Andrew S. Miller, Julie M. Fox, Nurgun Kose, Thomas Klose, Arthur S. Kim, Robin Bombardi, Rashika N. Tennekoon, Aruna Dharshan De Silva, Robert H. Carnahan, Michael Diamond, Michael G. Rossmann, Richard Kühn, James E. Crowe   +13 more
openalex   +2 more sources

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

A chikungunya virus–like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans

Science Translational Medicine, 2023
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle–adjuvanted vaccine (PXVX0317) from samples obtained ...
S. Raju, L. Adams, J. T. Earnest, Kelly L. Warfield, L. Vang, J. Crowe, D. Fremont, M. Diamond   +7 more
semanticscholar   +1 more source

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein

PLoS Neglected Tropical Diseases, 2023
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
J. Powers, Zoe L. Lyski, W. Weber, Michael C. Denton, Magdalene M Streblow, Adam T. Mayo, Nicole N Haese, Chad D. Nix, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, W. Messer, D. Streblow   +12 more
semanticscholar   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +6 more sources

An Investigation of Culicoides (Diptera: Ceratopogonidae) as Potential Vectors of Medically and Veterinary Important Arboviruses in South Africa

Viruses, 2021
Culicoides-borne viruses such as bluetongue, African horse sickness, and Schmallenberg virus cause major economic burdens due to animal outbreaks in Africa and their emergence in Europe and Asia.
Jumari Snyman, Gert J. Venter, Marietjie Venter   +2 more
doaj   +1 more source