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The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ^®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow   +16 more
doaj   +2 more sources

Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

Microorganisms, 2019
Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it
Laura I. Levi, Marco Vignuzzi
doaj   +2 more sources

Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity [PDF]

Frontiers in Public Health
Arboviruses represent a global public health challenge. The lack of diagnostic protocols and the presence of asymptomatic infections complicate confirmatory diagnostics.
Andrea Valles-Morera, Tatiana Murillo, Jose Lizano-Bolaños, Sergio Gutierrez-Roche, Margarita Alvarado, Jonathan Alfaro-Alvarado, Gerardo Andrés Calvo-Salas, Grace Prado-Hidalgo, Johis Ortega, Eugenia Corrales-Aguilar   +9 more
doaj   +2 more sources

Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents [PDF]

Viruses
Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world.
Kenneth Lundstrom
doaj   +2 more sources

Alphaviruses in Gene Therapy [PDF]

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +6 more sources

Low capacity for molecular detection of Alphaviruses other than Chikungunya virus in 23 European laboratories, March 2022. [PDF]

PLoS ONE
Alphaviruses comprise over 30 identified species spread worldwide and carry a large global health burden. With vector expansion occurring in and around Europe, it is anticipated this burden will increase.
Laura Pezzi, Ramona Moegling, Cécile Baronti, Kamelia R Stanoeva, Lance D Presser, Pauline Jourdan, Nazli Ayhan, Willem M R van den Akker, Stephan Zientara, Céline M Gossner, Rémi N Charrel, Chantal B E M Reusken, EVD-LabNet   +12 more
doaj   +2 more sources

Eilat virus isolated from Culex univittatus mosquitoes from the Namibian Zambezi Region influences in vitro superinfection with alpha- and flaviviruses in a virus-species-dependent manner. [PDF]

PLoS ONE
The genus Alphavirus harbors arboviruses of great concern, such as the Chikungunya virus and the equine encephalitis viruses. Transmission of pathogenic alphaviruses by mosquitoes could be influenced by insect-specific alphaviruses such as Eilat virus ...
Heiko D Guggemos, Anne Kopp, Katrin Voigt, Matthias Fendt, Selina L Graff, John K E Mfune, Christian Borgemeister, Sandra Junglen   +7 more
doaj   +2 more sources

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

Encephalitic alphaviruses [PDF]

Veterinary Microbiology, 2010
This review will cover zoonotic, encephalitic alphaviruses in the family Togaviridae. Encephalitic alphaviruses, i.e. Western- (WEEV), Eastern- (EEEV), Venezuelan equine encephalitis virus (VEEV) and, more rarely, Ross River virus, Chikungunya virus and Highlands J virus (HJV), are neuroinvasive and may cause neurological symptoms ranging from mild (e ...
Michele A, Zacks, Slobodan, Paessler
openaire   +2 more sources

A chikungunya virus–like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans

Science Translational Medicine, 2023
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle–adjuvanted vaccine (PXVX0317) from samples obtained ...
S. Raju, L. Adams, J. T. Earnest, Kelly L. Warfield, L. Vang, J. Crowe, D. Fremont, M. Diamond   +7 more
semanticscholar   +1 more source