Results 31 to 40 of about 15,705 (275)

Seroprevalence of Alphaviruses (Togaviridae) among Urban Population in Nouakchott, Mauritania, West Africa

open access: yesViruses, 2023
The presence of alphaviruses, such as chikungunya virus (CHIKV), has never been reported in Mauritania. We assessed the seroprevalence of CHIKV among Nouakchott residents.
Bedia Abdoullah   +8 more
semanticscholar   +1 more source

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses

open access: yesViruses, 2023
New World alphaviruses including Venezuelan Equine Encephalitis Virus (VEEV) and Eastern Equine Encephalitis Virus (EEEV) are mosquito-transmitted viruses that cause disease in humans and equines.
Niloufar A. Boghdeh   +8 more
semanticscholar   +1 more source

Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells [PDF]

open access: yesAdvances in Virology, 2011
Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans. Their potential threat to human health was most recently exemplified by the 2005 Chikungunya virus outbreak in La Reunion ...
Jason Yat-Sing Leung   +2 more
openaire   +4 more sources

Encephalitic alphaviruses [PDF]

open access: yesVeterinary Microbiology, 2010
This review will cover zoonotic, encephalitic alphaviruses in the family Togaviridae. Encephalitic alphaviruses, i.e. Western- (WEEV), Eastern- (EEEV), Venezuelan equine encephalitis virus (VEEV) and, more rarely, Ross River virus, Chikungunya virus and Highlands J virus (HJV), are neuroinvasive and may cause neurological symptoms ranging from mild (e ...
Michele A, Zacks, Slobodan, Paessler
openaire   +2 more sources

Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses.

open access: yesJournal of Infectious Diseases, 2023
The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human pathogens with the potential to spread to near pandemic proportions. Most of these are zoonotic, with spillover infections of humans and domestic animals, but a few such as ...
A. Powers   +7 more
semanticscholar   +1 more source

Perspectives for applying Alphaviruses in antitumor therapy

open access: yesИнфекция и иммунитет, 2023
Oncolytic viral therapy is a promising approach for treating tumors. Oncolytic viruses can directly lyse tumor cells and indirectly activate antitumor immunity.
Alina S. Nazarenko   +5 more
doaj   +1 more source

Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses

open access: yesJournal of Virology, 2022
Due to decades of inadequate monitoring and lack of vaccines and specific treatment, a large number of people have been infected with alphaviruses. GETV is a re-emerging alphavirus that has the potential to infect humans.
Ningning Wang   +7 more
semanticscholar   +1 more source

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

open access: yesViruses, 2021
Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations ...
Ivanildo P. Sousa   +6 more
doaj   +1 more source

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

open access: yesPathogens, 2022
Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines.
A. Leung   +3 more
semanticscholar   +1 more source

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors

open access: yesMicroorganisms, 2021
Despite the emerging threat of the Mayaro virus (MAYV) in Central and South-America, there are no licensed antivirals or vaccines available for this neglected mosquito-borne virus.
Lana Langendries   +3 more
doaj   +1 more source

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