Results 51 to 60 of about 15,705 (275)

Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity

open access: yesJournal of Virology, 2022
Alphaviruses are human pathogens that cause both debilitating acute and chronic musculoskeletal disease and potentially fatal encephalitis. In this study, we determined that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein ...
C. Lucas   +4 more
semanticscholar   +1 more source

Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells

open access: yesMicrobiology Spectrum, 2023
Most alphaviruses are transmitted by mosquito vectors and infect a wide range of vertebrate hosts, with a few exceptions. Eilat virus (EILV) in this genus is characterized by a host range restricted to mosquitoes. Its chimeric viruses have been developed
Lu Tan   +3 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

open access: yes, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K.   +10 more
core   +1 more source

Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses [PDF]

open access: yesOpen Biology, 2019
Arboviruses that are transmitted to humans by mosquitoes represent one of the most important causes of febrile illness worldwide. In recent decades, we have witnessed a dramatic re-emergence of several mosquito-borne arboviruses, including dengue virus ...
Liliana Echavarria-Consuegra   +2 more
doaj   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

open access: yes, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna   +3 more
core   +1 more source

Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance Arthritogenic alphaviruses, such as Chikungunya virus (CHIKV) and Mayaro virus (MAYV), cause febrile illness, rash, and a debilitating chronic polyarthritis in humans.
Ryan J. Malonis   +11 more
semanticscholar   +1 more source

Dissection of virus-host cell interactions in the early response to infection [PDF]

open access: yes, 2014
Stress granules (SG) are dynamic RNA/protein assemblies in the cytoplasm of the cell, formed under conditions of oxidative stress, heat shock or viral infections.
Panas, Marc D.
core   +4 more sources

Circulation of 2 Barmah Forest Virus Lineages in Military Training Areas, Australia

open access: yesEmerging Infectious Diseases, 2020
During 2017–2018, Barmah Forest virus was recovered from mosquitoes trapped in military training areas in Australia and from a soldier infected at 1 of these areas.
Wenjun Liu   +9 more
doaj   +1 more source

Recombinant Virus Quantification Using Single-Cell Droplet Digital PCR: A Method for Infectious Titer Quantification

open access: yesViruses, 2023
The quantification of viruses is necessary for both research and clinical applications. The methods available for RNA virus quantification possess several drawbacks, including sensitivity to inhibitors and the necessity of a standard curve generation ...
Ksenija Korotkaja, Anna Zajakina
doaj   +1 more source

Replication of the genome of alphaviruses [PDF]

open access: yesJournal of Cell Science, 1987
ABSTRACT The genome of Semliki Forest virus (SFV) is 11 442 nucleotides with a 5′ cap-structure and a 3′ poly(A) tail of about 100 residues. The genome of the closely related Sindbis virus (SIN) is slightly longer (11 703 nucleotides). The parental RNA is first translated from the 5′ two thirds to yield; nsPl, nsP2, nsP3 and nsP4, which ...
L, Kääriäinen   +3 more
openaire   +2 more sources

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