Results 51 to 60 of about 15,327 (237)
ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]
, 2019 Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea +6 more
core +2 more sources
Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
K. Lundstrom
semanticscholar +1 more source
Viruses, 2019 Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of the Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash and incapacitating poly-arthralgia ...
Yessica Y. Llamas-González +4 more
doaj +1 more source
Journal of Virology, 2022 Alphaviruses are human pathogens that cause both debilitating acute and chronic musculoskeletal disease and potentially fatal encephalitis. In this study, we determined that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein ...
C. Lucas +4 more
semanticscholar +1 more source
Encephalitic Alphaviruses [PDF]
, 2016 Alphaviruses comprise a fascinating group of small, enveloped single-stranded positive-sense RNA viruses. They are usually transmitted by arthropod vectors (usually mosquitoes). Of the thirty known species, eight are important human pathogens (e.g. Venezuelan equine encephalitis virus) whilst one, salmonid alphavirus, is of economic importance to the ...
Clive S. McKimmie, John K. Fazakerley
openaire +3 more sources
Frontiers in Microbiology, 2021 Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the Togaviridae family.
Lien De Caluwé +8 more
semanticscholar +1 more source
Dissection of virus-host cell interactions in the early response to infection [PDF]
, 2014 Stress granules (SG) are dynamic RNA/protein assemblies in the cytoplasm of the cell, formed under conditions of oxidative stress, heat shock or viral infections.
Panas, Marc D.
core +4 more sources
Microbiology Spectrum, 2023 Most alphaviruses are transmitted by mosquito vectors and infect a wide range of vertebrate hosts, with a few exceptions. Eilat virus (EILV) in this genus is characterized by a host range restricted to mosquitoes. Its chimeric viruses have been developed
Lu Tan +3 more
doaj +1 more source
Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]
, 2015 Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K. +10 more
core +1 more source
Packaging signals in alphaviruses [PDF]
Journal of Virology, 1997 Alphaviruses synthesize large amounts of both genomic and subgenomic RNA in infected cells, but usually only the genomic RNA is packaged. This implies the existence of an encapsidation or packaging signal which would be responsible for selectivity. Previously, we had identified a region of the Sindbis virus genome that interacts specifically with the ...
E, Frolova, I, Frolov, S, Schlesinger
openaire +2 more sources