Results 61 to 70 of about 15,258 (179)

Co-circulation of two Alphaviruses in Burkina Faso: Chikungunya and O’nyong nyong viruses

PLoS Neglected Tropical Diseases
Background Chikungunya virus (CHIKV) and O’nyong nyong virus (ONNV) are phylogenetically related alphaviruses in the Semliki Forest Virus (SFV) antigenic complex of the Togaviridae family. There are limited data on the circulation of these two viruses in
B. Tinto, Brice Bicaba, T. Kagoné, J. Kayiwa, Ingrid B. Rabe, Corinne Simone Collette Merle, Alidou Zango, A. Ayouba, Sara Salinas, D. Kania, Y. Simonin   +10 more
semanticscholar   +1 more source

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core  

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus [PDF]

, 2003
Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses.
AJ Johnson, BD Lindenbach, BU Barth, CT Jones, DLD Caspar, DS Burke, DWC Beasley, EJ Mancini, FA Rey, FX Heinz, GW Smith, IC Lorenz, J Lescar, James H Strauss, Jeroen Corver, JH Strauss, JH Strauss, JJB Cockburn, JT Roehrig, K Stiasny, LJ McGuffin, MG Rossmann, MG Rossmann, Michael G Rossmann, ML Ng, N Grigorieff, Paul R Chipman, Peter R Johnson, PJL Werten, Richard J Kuhn, RJ Kuhn, S Bhardwaj, S Elshuber, S Lee, SL Allison, SL Allison, Suchetana Mukhopadhyay, T Solomon, Timothy S Baker, U Skoging, VM Unger, W Zhang, WD Crill, Wei Zhang, Y Ji, Y Modis, Y Zhang, Ying Zhang, YS Hahn   +48 more
core   +1 more source

Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti

PLoS Neglected Tropical Diseases
Wolbachia pipientis (= Wolbachia) has promise as a tool to suppress virus transmission by Aedes aegypti mosquitoes. However, Wolbachia can have variable effects on mosquito-borne viruses.
Brittany L. Dodson, S. Pujhari, M. Brustolin, Hillery C. Metz, J. Rasgon   +4 more
semanticscholar   +1 more source

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

Nature Communications, 2020
Mayaro virus (MAYV) is an emerging arbovirus of the Americas that may cause a debilitating arthritogenic disease. The biology of MAYV is not fully understood and largely inferred from related arthritogenic alphaviruses.
H. Ribeiro-Filho, L. D. Coimbra, Alexandre Cassago, R. Rocha, João V. S. Guerra, Rafael de Felício, Carolina Moretto Carnieli, Luiza B. P. Leme, A. C. Padilha, A. P. Paes Leme, D. Trivella, R. Portugal, P. Lopes-de-Oliveira, R. E. Marques   +13 more
semanticscholar   +1 more source

Differential susceptibility of human microglia HMC3 cells and brain microvascular endothelial HBEC-5i cells to Mayaro and Una virus infection

Frontiers in Virology
Mayaro (MAYV) and Una (UNAV) are emerging alphaviruses circulating in the Americas. Earlier reports have revealed that MAYV infects different human cell lines, including synovial and dermal fibroblasts, chondrocytes, osteoblasts, astrocytes and pericytes,
Dalkiria Campos, Madelaine Sugasti-Salazar, Madelaine Sugasti-Salazar, Patricia Valdés-Torres, Patricia Valdés-Torres, Paola Elaine Galán-Jurado, Dalel Zegarra, Dalel Zegarra, José González-Santamaría   +8 more
doaj   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S., Strauss, Ellen G., Strauss, James H.   +2 more
core   +1 more source

Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses

PLoS Neglected Tropical Diseases, 2021
Mayaro virus (MAYV) is an alphavirus endemic to South and Central America associated with sporadic outbreaks in humans. MAYV infection causes severe joint and muscle pain that can persist for weeks to months.
J. Powers, Nicole N Haese, Michael C. Denton, Takeshi Ando, C. Kreklywich, Kiley Bonin, Cassilyn E Streblow, Nicholas Kreklywich, Patsy Smith, Rebecca M. Broeckel, Victor R. Defilippis, T. Morrison, M. Heise, D. Streblow   +13 more
semanticscholar   +1 more source

The Host Non-Coding RNA Response to Alphavirus Infection

Viruses, 2023
Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
doaj   +1 more source

Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]

, 2015
Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena, Esteban, Mariano, Nájera García, José Luis, Toribio, René, Ventoso, Iván   +4 more
core   +1 more source