Results 71 to 80 of about 15,705 (275)

Cryogenic electron microscopy and tomography reveal imperfect icosahedral symmetry in alphaviruses

PNAS Nexus
Alphaviruses are spherical, enveloped RNA viruses with two-layered icosahedral architecture. The structures of many alphaviruses have been studied using cryogenic electron microscopy (cryo-EM) reconstructions, which impose icosahedral symmetry on the ...
D. Chmielewski, Guan-Chin Su, J. Kaelber, G. Pintilie, Muyuan Chen, Jing Jin, A. J. Auguste, Wah Chiu   +7 more
semanticscholar   +1 more source

In Vitro Inhibition of Alphaviruses by Lycorine

Virologica Sinica, 2021
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection.
Na Li, Zhen Wang, Rui Wang, Zhe-Rui Zhang, Yanan Zhang, Chenglin Deng, Bo Zhang, Lu Shang, Hanqing Ye   +8 more
semanticscholar   +1 more source

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus [PDF]

, 2003
Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses.
AJ Johnson, BD Lindenbach, BU Barth, CT Jones, DLD Caspar, DS Burke, DWC Beasley, EJ Mancini, FA Rey, FX Heinz, GW Smith, IC Lorenz, J Lescar, James H Strauss, Jeroen Corver, JH Strauss, JH Strauss, JJB Cockburn, JT Roehrig, K Stiasny, LJ McGuffin, MG Rossmann, MG Rossmann, Michael G Rossmann, ML Ng, N Grigorieff, Paul R Chipman, Peter R Johnson, PJL Werten, Richard J Kuhn, RJ Kuhn, S Bhardwaj, S Elshuber, S Lee, SL Allison, SL Allison, Suchetana Mukhopadhyay, T Solomon, Timothy S Baker, U Skoging, VM Unger, W Zhang, WD Crill, Wei Zhang, Y Ji, Y Modis, Y Zhang, Ying Zhang, YS Hahn   +48 more
core   +1 more source

Chikungunya virus and other emerging arthritogenic alphaviruses

Nature Reviews Microbiology
William Marciel de Souza, Marc Lecuit, Scott C. Weaver   +2 more
openalex   +3 more sources

Co-circulation of two Alphaviruses in Burkina Faso: Chikungunya and O’nyong nyong viruses

PLoS Neglected Tropical Diseases
Background Chikungunya virus (CHIKV) and O’nyong nyong virus (ONNV) are phylogenetically related alphaviruses in the Semliki Forest Virus (SFV) antigenic complex of the Togaviridae family. There are limited data on the circulation of these two viruses in
B. Tinto, Brice Bicaba, T. Kagoné, J. Kayiwa, Ingrid B. Rabe, Corinne Simone Collette Merle, Alidou Zango, A. Ayouba, Sara Salinas, D. Kania, Y. Simonin   +10 more
semanticscholar   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, EarlyView.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core  

Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti

PLoS Neglected Tropical Diseases
Wolbachia pipientis (= Wolbachia) has promise as a tool to suppress virus transmission by Aedes aegypti mosquitoes. However, Wolbachia can have variable effects on mosquito-borne viruses.
Brittany L. Dodson, S. Pujhari, M. Brustolin, Hillery C. Metz, J. Rasgon   +4 more
semanticscholar   +1 more source

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Nature, 2018
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease1.
Rong Zhang, A. S. Kim, J. Fox, S. Nair, K. Basore, W. Klimstra, Rebecca Rimkunas, Rachel H. Fong, Hueylie Lin, S. Poddar, J. Crowe, B. Doranz, D. Fremont, M. Diamond   +13 more
semanticscholar   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source