Results 1 to 10 of about 1,609,187 (354)

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]

Clinical & Translational Immunology, 2023
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius   +14 more
doaj   +2 more sources

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]

Frontiers in Immunology
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira   +6 more
doaj   +2 more sources

Thrombotic microangiopathy mediates poor prognosis among lupus nephritis via complement lectin and alternative pathway activation [PDF]

Frontiers in Immunology, 2022
ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
doaj   +2 more sources

The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs

Frontiers in Immunology, 2022
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj   +1 more source

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

Frontiers in Immunology, 2022
The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1 ...
Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine   +8 more
doaj   +1 more source

Resolution of Joint Molecules by RuvABC and RecG Following Cleavage of the Escherichia coli Chromosome by EcoKI [PDF]

, 2009
DNA double-strand breaks can be repaired by homologous recombination involving the formation and resolution of Holliday junctions. In Escherichia coli, the RuvABC resolvasome and the RecG branch-migration enzyme have been proposed to act in alternative ...
Leach, David, Okely, Ewa, Wardrope, Laura   +2 more
core   +10 more sources

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
doaj   +1 more source

Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy

Frontiers in Immunology, 2021
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous reports suggest that TA-TMA is caused by complement activation by complement-related genetic ...
Hiroshi Okamura, Hirohisa Nakamae, Takero Shindo, Katsuki Ohtani, Katsuki Ohtani, Yoshihiko Hidaka, Yasufumi Ohtsuka, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Naonori Harada, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Asao Hirose, Mika Nakamae, Nobutaka Wakamiya, Nobutaka Wakamiya, Masayuki Hino, Norimitsu Inoue, Norimitsu Inoue   +20 more
doaj   +1 more source

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V, Kelly, John M, Meyer, David J, Miles, Michael A, Taylor, Martin C, Wilkinson, Shane R   +5 more
core   +4 more sources