Alternative pathway diagnostics. [PDF]
SummaryUncontrolled alternative pathway activation is the primary driver of several diseases, and it contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor this arm of the complement system are increasingly important.
Thurman JM+2 more
europepmc +3 more sources
Alternative patulin pathway unproven [PDF]
Letter to the Editor[Excerpt] We read with interest in your journal that Penicillium expansum strains S3, S31 and S87 ( Rharmitt et al., 2016) were considered negative for possession of the isoepoxydon dehydrogenase (idh) gene for patulin (PAT ...
Lima, Nelson+3 more
core +4 more sources
Alternative Macroautophagic Pathways [PDF]
Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which
Katrin Juenemann, Eric Reits
openaire +3 more sources
Resolution of Joint Molecules by RuvABC and RecG Following Cleavage of the Escherichia coli Chromosome by EcoKI [PDF]
DNA double-strand breaks can be repaired by homologous recombination involving the formation and resolution of Holliday junctions. In Escherichia coli, the RuvABC resolvasome and the RecG branch-migration enzyme have been proposed to act in alternative ...
Leach, David+2 more
core +9 more sources
An alternative pathway for alphavirus entry [PDF]
Abstract The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the ...
Dennis Brown+2 more
openaire +4 more sources
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T.+7 more
core +2 more sources
The alternative complement pathway revisited [PDF]
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Eirik Mollnes, Morten Harboe
openaire +2 more sources
COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ+4 more
core +1 more source
Missing linkers : an alternative pathway to UiO-66 electronic structure engineering [PDF]
UiO-66 is a promising metal-organic framework for photocatalytic applications. However, the ligand-to-metal charge transfer of an excited electron is inefficient in the pristine material.
De Vos, Arthur+4 more
core +3 more sources
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]
*Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky+17 more
core +3 more sources