Results 1 to 10 of about 782,609 (335)

Alternative pathway diagnostics. [PDF]

Immunol Rev, 2023
SummaryUncontrolled alternative pathway activation is the primary driver of several diseases, and it contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor this arm of the complement system are increasingly important.
Thurman JM, Thurman JM, Fremeaux-Bacchi V.   +2 more
europepmc   +3 more sources

Alternative pathways of T lymphocyte activation. [PDF]

The Journal of experimental medicine, 1978
Data presented in this paper suggest that there may be two alternative pathways which T lymphocytes can use in generating a cytotoxic response to alloantigens in vitro. First, there is the pathway taken when stimulator and responder cells differ by an entire H-2 complex where Ly1+2- helper T lymphocytes respond to I region encoded lymphocyte defined ...
Fritz H. Bach, Benedict J. Alter
openalex   +5 more sources

Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies [PDF]

Current Issues in Molecular Biology, 2023
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (HeBPs)
Stefanos A. Tsiftsoglou
doaj   +2 more sources

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]

Frontiers in Immunology
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira   +6 more
doaj   +2 more sources

The dynamics of alternative pathways to compensatory substitution [PDF]

arXiv, 2013
The role of epistatic interactions among loci is a central question in evolutionary biology and is increasingly relevant in the genomic age. While the population genetics of compensatory substitution have received considerable attention, most studies have focused on the case when natural selection is very strong against deleterious intermediates.
arxiv   +6 more sources

Corrigendum: Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese [PDF]

Frontiers in Immunology, 2022
Dian-Chun Shi, Dian-Chun Shi, Dian-Chun Shi, Shao-Zhen Feng, Shao-Zhen Feng, Zhong Zhong, Zhong Zhong, Lu Cai, Lu Cai, Meng Wang, Meng Wang, Dong-Ying Fu, Dong-Ying Fu, Xue-Qing Yu, Xue-Qing Yu, Xue-Qing Yu, Ming Li, Ming Li, Ming Li   +18 more
doaj   +2 more sources

AAPM Task Group 298: Recommendations on certificate program/alternative pathway candidate education and training. [PDF]

J Appl Clin Med Phys, 2022
Abstract Entry into the field of clinical medical physics is most commonly accomplished through the completion of a Commission on Accreditation of Medical Physics Educational Programs (CAMPEP)‐accredited graduate and residency program. To allow a mechanism to bring valuable expertise from other disciplines into clinical practice in medical physics, an “
Prisciandaro JI, Burmeister JW, DeLuca PM, Gerbi BJ, Giger ML, Robar JL, Seibert JA.   +6 more
europepmc   +2 more sources

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

Frontiers in Immunology, 2022
The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1 ...
Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine   +8 more
doaj   +1 more source

The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs

Frontiers in Immunology, 2022
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj   +1 more source

Alternative Macroautophagic Pathways [PDF]

International Journal of Cell Biology, 2012
Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which
Katrin Juenemann, Eric Reits
openaire   +3 more sources