Results 1 to 10 of about 6,006,467 (356)
Alternative pathway diagnostics. [PDF]
Immunol Rev, 2023 Uncontrolled alternative pathway activation is the primary driver of several diseases, and it contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor this arm of the complement system are increasingly important.
Thurman JM +2 more
europepmc +4 more sources
Assessment of the Role of C3(H2O) in the Alternative Pathway
Frontiers in Immunology, 2020 In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system.
Karin Fromell +9 more
doaj +2 more sources
Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies [PDF]
Current Issues in Molecular Biology, 2023 Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (HeBPs)
Stefanos A. Tsiftsoglou
doaj +2 more sources
Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]
Frontiers in ImmunologyChagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon +6 more
doaj +2 more sources
Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis [PDF]
Frontiers in ImmunologyIntroductionEpidermolysis Bullosa Acquisita (EBA) is an autoimmune blistering dermatosis characterized by autoantibodies (AAbs) against type VII collagen (COL7) located at the dermal epidermal junction (DEJ).
Björn Laffer +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1 ...
Kohei Kusakari +8 more
doaj +1 more source
The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs
Frontiers in Immunology, 2022 ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj +1 more source
Frontiers in Immunology, 2020 The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen +8 more
doaj +1 more source
Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
doaj +1 more source
Alternative Pathway Involvement in Protoporphyria Patients Related to Sun Exposure
Frontiers in Immunology, 2021 The homeostasis of tissues in a chronic disease is an essential function of the alternative pathway (AP) of the complement system (CS). However, if not controlled, it may also be detrimental to healthy cells with a consequent aggravation of symptoms. The
Francesca Granata +9 more
doaj +1 more source