Results 171 to 180 of about 4,775,639 (287)

Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases. [PDF]

Immunol Rev, 2023
Rodríguez de Córdoba S.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

<i>Moss-derived</i> recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy. [PDF]

Front Immunol
Imanifard Z, Penati F, Padoa S, Dabrowska-Schlepp P, Bresin E, Peracchi T, Benigni A, Remuzzi G, Noris M, Donadelli R.   +9 more
europepmc   +1 more source

Correction to: Mathematical Modelling of Alternative Pathway of Complement System. [PDF]

Bull Math Biol, 2021
Bakshi S, Cunningham F, Nichols EM, Biedzka-Sarek M, Neisen J, Petit-Frere S, Bessant C, Bansal L, Peletier LA, Zamuner S, van der Graaf PH.   +10 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease. [PDF]

Adv Sci (Weinh)
Chen YH, Zhu RX, Zhang NX, Sun TT, Zhang XW, Zhao YJ, He BY, Yao H, Du RH, Cao L, Zhang WB, Liu WG, Cai Y, Wang C, Hu G, Wei Y, Liu Y, Lu M.   +17 more
europepmc   +1 more source

Bacterial outer membrane vesicles provide an alternative pathway for trafficking of <i>Escherichia coli</i> O157 type III secreted effectors to epithelial cells. [PDF]

mSphere, 2023
Sirisaengtaksin N, O'Donoghue EJ, Jabbari S, Roe AJ, Krachler AM.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Chronic kidney disease enhances alternative pathway activity: a new paradigm. [PDF]

J Clin Invest
Jalal DI, Thurman JM, Smith RJ.
europepmc   +1 more source

The potential role of complement alternative pathway activation in hypertensive renal damage. [PDF]

Exp Biol Med (Maywood), 2022
Wang C, Wang Z, Zhang W.
europepmc   +1 more source