Results 181 to 190 of about 7,204,743 (394)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies. [PDF]

Curr Issues Mol Biol, 2023
Tsiftsoglou SA.
europepmc   +1 more source

Maternal and Fetal Alternative Complement Pathway Activation in Early Severe Preeclampsia

, 2013
M. Camille Hoffman, Kristen K. Rumer, Anita Kramer, Anne M. Lynch, Virginia D. Winn   +4 more
openalex   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Hepatic Transcriptome Comparative In Silico Analysis Reveals Similar Pathways and Targets Altered by Legacy and Alternative Per- and Polyfluoroalkyl Substances in Mice [PDF]

, 2023
Dakota R. Robarts, Jiayin Dai, Christopher Lau, Udayan Apte, J. Christopher Corton   +4 more
openalex   +1 more source

An alternative pathway to plant cold tolerance in the absence of vacuolar invertase activity. [PDF]

Plant J, 2023
Teper-Bamnolker P, Roitman M, Katar O, Peleg N, Aruchamy K, Suher S, Doron-Faigenboim A, Leibman D, Omid A, Belausov E, Andersson M, Olsson N, Fält AS, Volpin H, Hofvander P, Gal-On A, Eshel D.   +16 more
europepmc   +1 more source

Determination of optimal in vitro conditions for camel alternative complement pathway assay

, 2001
V. Chopra, Sonu Kashyap
openalex   +2 more sources

The acidic pathway of bile acid synthesis: Not just an alternative pathway

Liver Research, 2019
W. Pandak, Genta Kakiyama
semanticscholar   +1 more source