Results 11 to 20 of about 782,609 (335)

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira   +8 more
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Alternative Pathway Involvement in Protoporphyria Patients Related to Sun Exposure

Frontiers in Immunology, 2021
The homeostasis of tissues in a chronic disease is an essential function of the alternative pathway (AP) of the complement system (CS). However, if not controlled, it may also be detrimental to healthy cells with a consequent aggravation of symptoms. The
Francesca Granata, Lorena Duca, Valentina Brancaleoni, Silvia Fustinoni, Silvia Fustinoni, Giacomo De Luca, Irene Motta, Irene Motta, Giovanna Graziadei, Elena Di Pierro   +9 more
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Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
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Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy

Frontiers in Immunology, 2021
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous reports suggest that TA-TMA is caused by complement activation by complement-related genetic ...
Hiroshi Okamura, Hirohisa Nakamae, Takero Shindo, Katsuki Ohtani, Katsuki Ohtani, Yoshihiko Hidaka, Yasufumi Ohtsuka, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Naonori Harada, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Asao Hirose, Mika Nakamae, Nobutaka Wakamiya, Nobutaka Wakamiya, Masayuki Hino, Norimitsu Inoue, Norimitsu Inoue   +20 more
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Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
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Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

Frontiers in Immunology, 2021
BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi, Corentin Leroy, Corentin Leroy, Olivier Epaulard, Olivier Epaulard, Giovanna Clavarino, Antoine Vilotitch, Marion Le Marechal, Marie-Christine Jacob, Tatiana Raskovalova, Martine Pernollet, Audrey Le Gouellec, Audrey Le Gouellec, Jean-Luc Bosson, Pascal Poignard, Pascal Poignard, Matthieu Roustit, Matthieu Roustit, Nicole Thielens, Chantal Dumestre-Pérard, Chantal Dumestre-Pérard, Jean-Yves Cesbron   +21 more
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An alternative pathway for alphavirus entry [PDF]

Virology Journal, 2011
Abstract The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the ...
Dennis Brown, Raquel Hernandez, Joseph P. Kononchik   +2 more
openaire   +4 more sources

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source