Results 211 to 220 of about 782,609 (335)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Suppression of endometriosis by miRNA-34a via inhibition of matrix metalloproteinase-2: An alternative pathway to impede invasion. [PDF]

Noncoding RNA Res
Begum Y, Pandit A, Shukla D, Gupta R, DasMahapatra P, Srivastava AK, Swarnakar S.   +6 more
europepmc   +1 more source

Alternative pathway activation in pregnancy, a measured amount "complements" a successful pregnancy, too much results in adverse events. [PDF]

Immunol Rev, 2023
Smith-Jackson K, Harrison RA.
europepmc   +1 more source

The Ability of Smooth and Rough Strains of Streptococcus Pneumoniae to Activate Human Complement by the Alternative Pathway

, 1978
M S Edwards, J. M. Stark
openalex   +1 more source

Influence of surface modulations by enzymes and monoclonal antibodies on alternative complement pathway activation by Yersinia enterocolitica [PDF]

, 1989
Elmar Wächter, Volker Brade
openalex   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins. [PDF]

Sci Rep
Tricou LP, Mouton W, Cara A, Trouillet-Assant S, Bouvard D, Laurent F, Diot A, Josse J.   +7 more
europepmc   +1 more source

C3 binds covalently to the Cγ3 domain of IgG immune aggregates during complement activation by the alternative pathway [PDF]

, 1989
Luis C. Antón, J.M. Alcolea, Pilar Sánchez‐Corral, Guillermo Marqués, Angel Sánchez, Fernando Vivanco   +5 more
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies. [PDF]

Sci Rep
Yang Y, Zhang Y, Li Y, Zhou X, Honda K, Kang D, Wang M, Yang JH, Xia Z, Wei Y, Liu L, Hu R, Takaki T, Xing G.   +13 more
europepmc   +1 more source