Results 131 to 140 of about 11,756 (178)
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Roles of free GPIs in amastigotes of Leishmania
Molecular and Biochemical Parasitology, 1999Glycosylated phosphatidylinositols (GPIs) are abundant cell surface molecules of the Leishmania. Amastigote-specific GPIs AmGPI-Y and AmGPI-Z, both ethanolamine (EtN)-containing glycolipids, were identified in Leishmania amazonensis. A paucity of GPI-anchored proteins in amastigotes of L.
K, Mensa-Wilmot +7 more
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Leishmania amazonensis: Acidic organelles in amastigotes
Experimental Parasitology, 1988Leishmania amastigotes are intracellular protozoan parasites which exclusively invade cells of the macrophage series and multiply within phagolysosomes. Recent studies showed that intracellular and isolated amastigotes of L. amazonesis are killed by amino acid esters which appear to be trapped within as yet unidentified, possibly acidified, "lysosome ...
J C, Antoine +3 more
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Leishmania amazonensis:The Phagocytosis of Amastigotes by Macrophages
Experimental Parasitology, 1998In the present study, we examine the cell biology of Leishmania amastigote uptake by mammalian cells and compare this process to the phagocytosis of IgG-opsonized erythrocytes. We report that many aspects of amastigote uptake into macrophages resemble classical receptor-mediated phagocytosis.
D C, Love, M, Mentink Kane, D M, Mosser
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Leishmania mexicana: Energy metabolism of amastigotes and promastigotes
Experimental Parasitology, 1982Abstract The utilisation of substrates by Leishmania mexicana amastigotes and promastigotes differed significantly. The rates of uptake and catabolism of nonesterified fatty acids were up to 10-fold higher with amastigotes. Almost all the available exogenous fatty acids were consumed during amastigote transformation and by stationary phase of ...
D T Hart, G H Coombs
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An amastigote phase of the sleeping sickness trypanosome
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971Abstract 1. 1. We have found amastigotes closely packed together with “white thrombus” in capillaries, in sections of the choroid plexus of rats which had been infected with a strain of Trypanosoma brucei isolated from man in Botswana. 2. 2.
W E, Ormerod, S, Venkatesan
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Living in a phagolysosome; metabolism of Leishmania amastigotes
Trends in Parasitology, 2007Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage.
Malcolm J, McConville +4 more
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Characterization of Leishmania (Leishmania) tropica axenic amastigotes
Acta Tropica, 2010Optimum conditions for generating Leishmania (Leishmania) tropica axenic amastigotes (AxA) in culture were determined, pH 5.5/36 degrees C, and the parasites characterized by different techniques, including light microscopy, macrophage infection, stage specific antigen expression and differential display. AxA were morphologically similar to amastigotes
Abedelmajeed Nasereddin +2 more
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Experimental Parasitology, 1984
Leishmania mexicana mexicana promastigotes, axenic amastigotes, and amastigotes derived from Vero cells were examined for de novo purine synthesis and mechanisms of purine salvage. Both promastigotes and axenic amastigotes were incapable of de novo purine synthesis, as shown by the lack of [14C]formate and [14C]glycine incorporation into purine ...
B D, Hansen +3 more
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Leishmania mexicana mexicana promastigotes, axenic amastigotes, and amastigotes derived from Vero cells were examined for de novo purine synthesis and mechanisms of purine salvage. Both promastigotes and axenic amastigotes were incapable of de novo purine synthesis, as shown by the lack of [14C]formate and [14C]glycine incorporation into purine ...
B D, Hansen +3 more
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Axenic culture of Leishmania Amastigotes
Parasitology Today, 1993One of the future goals in Leishmania research will be to reproduce the entire life cycle oxenically, in vitro. In this article, Paul Bates reviews recent progress in the axenic culture of amastigotes and addresses some of the remaining problems associated with culture methods for both amostigote and promostigote forms.
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An antigenically distinct lipophosphoglycan on amastigotes of Leishmania major
Molecular and Biochemical Parasitology, 1991We show that lipophosphoglycan (LPG) on the surface of amastigotes of Leishmania major is antigenically and biochemically distinct from promastigote LPG. A rabbit antiserum raised against the amastigote integral membrane fraction detected LPG spanning the region of Mr 55,000-100,000 on Western blots of the amastigote integral membrane fraction, but did
T A, Glaser +4 more
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