Results 11 to 20 of about 11,756 (178)

Infectivity of amastigotes of Trypanosoma cruzi [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1986
The infectivity amastigotes of Trypanosoma cruzi, isolated from the supernatant of the J774G8 macrophage-like cell line infected with trypomastigotes to normal macrophages in vitro was tested. After a period of 1 h of T.
Tecia Ulisses de Carvalho, Wanderley de Souza   +1 more
doaj   +3 more sources

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review. [PDF]

Chem Biol Drug Des
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
da Veiga Oliveira ME, Dyminski Parente Ribeiro E, Guenther OHP, Tomiotto-Pellissier F.   +3 more
europepmc   +2 more sources

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]

Immunology
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Barros ABB, Leite GA, de Andrade AG, Reis MDDS, Cavalcante-Silva LHA, Lins MP.   +5 more
europepmc   +2 more sources

Amastigote Synapse: The Tricks of Trypanosoma cruzi Extracellular Amastigotes [PDF]

Frontiers in Microbiology, 2018
To complete its life cycle within the mammalian host, Trypanosoma cruzi, the agent of Chagas' disease, must enter cells. Trypomastigotes originating from the insect vector (metacyclic) or from infected cells (bloodstream/tissue culture-derived) are the classical infective forms of the parasite and enter mammalian cells in an actin-independent manner ...
Bonfim-Melo, Alexis, Ferreira, Eden R., Florentino, Pilar T.V., Mortara, Renato A.   +3 more
openaire   +6 more sources

An axenic amastigote system for drug screening [PDF]

Antimicrobial Agents and Chemotherapy, 1997
Currently available primary screens for selection of candidate antileishmanial compounds are not ideal. The choices include screens that are designed to closely reflect the situation in vivo but are labor-intensive and expensive (intracellular amastigotes and animal models) and screens that are designed to facilitate rapid testing of a large number of ...
H L, Callahan, A C, Portal, R, Devereaux, M, Grogl   +3 more
openaire   +2 more sources

Endocytosis and Sphingolipid Scavenging inLeishmania mexicanaAmastigotes [PDF]

Biochemistry Research International, 2012
Leishmaniaspecies are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example,Leishmaniaspecies utilise host sphingolipid for synthesis of complex sphingolipid. In this studyL.
Ali, Hayder Z., Harding, Clare R., Denny, Paul W.   +2 more
openaire   +5 more sources

Analysis and chromosomal mapping of Leishmania (Leishmania) amazonensis amastigote expressed sequence tags

Memorias do Instituto Oswaldo Cruz, 2007
The characterization of expressed sequence tags (ESTs) generated from a cDNA library of Leishmania (Leishmania) amazonensis amastigotes is described. The sequencing of 93 clones generated new L. (L.) amazonensis ESTs from which 32% are not related to any
Luciana Girotto Gentil, Fernanda Lasakosvitsch, José Franco da Silveira, Márcia Regina Machado dos Santos, Clara Lúcia Barbiéri   +4 more
doaj   +1 more source

Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis

Memorias do Instituto Oswaldo Cruz, 2004
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis.
Lianet Monzote Fidalgo, Ana Margarita Montalvo Álvarez, Lisset Fonseca Geigel, Rolando Pérez Pineiro, Margarita Suárez Navarro, Hortensia Rodríguez Cabrera   +5 more
doaj   +1 more source

Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes [PDF]

Infection and Immunity, 1997
Induction of a glycosylphosphatidylinositol (GPI) deficiency in Trypanosoma cruzi by the heterologous expression of Trypanosoma brucei GPI-phospholipase C (GPI-PLC) results in decreased expression of major surface proteins (N. Garg, R. L. Tarleton, and K. Mensa-Wilmot, J. Biol. Chem. 272:12482-12491, 1997).
N, Garg, M, Postan, K, Mensa-Wilmot, R L, Tarleton   +3 more
openaire   +2 more sources

Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage.
María Cristina Vanrell, María Cristina Vanrell, Santiago José Martinez, Lucila Ibel Muñoz, Betiana Nebaí Salassa, Betiana Nebaí Salassa, Julián Gambarte Tudela, Patricia Silvia Romano, Patricia Silvia Romano   +8 more
doaj   +1 more source